阻塞性睡眠呼吸暂停低通气综合征与高血压  

The Relation between Obstructive Sleep Apnea-hypopnea Syndrome and Hypertension

作　　者：王晓源[1] 张林潮[1] 

机构地区：[1]广西医科大学附属柳州市人民医院呼吸内科,广西柳州545001

出　　处：《医学综述》2010年第20期3158-3160,共3页Medical Recapitulate

基　　金：柳州市科技攻关课题(2009030403)

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与高血压密切相关,OSAHS是引起高血压的独立危险因素,但其引起高血压的机制尚未十分清楚。睡眠中长期慢性间断性低氧、高碳酸血症,引起交感活性增加、内皮功能障碍、肾素-血管紧张素-醛固酮系统的激活,以及内皮素1、心钠素分泌的异常增多等都可能是高血压发生的重要因素。OSAHS合并的高血压是一种难治性高血压,单纯的药物治疗很难控制血压平稳,同时应用持续呼吸道正压通气是治疗的最佳方案。Objective Sleep apnea-hypopnea syndrome（OSAHS） and hypertension is closely related,OSAHS is an independent factor of hypertension,but the mechanism is not yet clear.Factors including the long-term chronic discontinuity low oxygen and the high carbohemia in sleep cause the consensus activeness increased,the endothelial disfunction,the renin-blood vessel tight element-aldosterone system′s activation,as well as endothelin 1,atrial natriuretic factor secretion exceptionally increases and so on Which may be the reasons for hypertension.OSAHS with hypertension is one kind of refractory hypertension,the pure pharmacological treatment is diffcult to keep blood pressure steady,simultaneously applies continuous postive airway pressure ventilation is the preferred plan.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 高血压 内皮素1 持续呼吸道正压通气 

分 类 号：R544.1[医药卫生—心血管疾病]