增强型体外反搏对高血压患者血管内皮功能的影响  

Enhanced external counterpulsation influences vascular endothelial function in hypertensive patients.

作　　者：余琴[1] 李新[1] 郑舒展[1] 熊英[1] 

机构地区：[1]泸州医学院附属医院心内科胸心外科,四川泸州646000

出　　处：《四川医学》2010年第10期1448-1450,共3页Sichuan Medical Journal

摘　　要：目的探讨增强型体外反搏(EECP)治疗对高血压患者血管内皮功能的影响。方法 36例高血压患者分为常规治疗组(CT,n=20),常规治疗+EECP组(CT+EECP,n=16)。EECP组隔天反搏治疗2h,总共反搏36h,36d。分别于体外反搏前、反搏后,采用高频超声检测肱动脉血流介导的内皮依赖血管舒张功能(FMD)方法,比较反搏组与非反搏组治疗前后FMD的变化。同时检测血浆内皮素(ET)、一氧化氮(NO)。结果 CT组、CT+EECP组治疗后FMD明显升高,分别为(5.05%±1.19%),P<0.05,(7.90%±0.74%)P<0.01,两组比较差异有统计学意义(P<0.05),CT+EECP组NMD也得到改善(P<0.05),而常规治疗组NMD无显著改善;两组患者经治疗后ET均明显下降(73.69±22.13,60.21±20.38,P<0.05和P<0.01)、NO均明显上升(69.67±23.36,80.21±22.87,P<0.05和P<0.01);EECP组下降更为显著,下降幅度与常规治疗组比较,差异有统计学意义(P<0.05)。结论增强型体外反搏可改善高血压患者血管内皮功能。Objective To explore the effect of Enhanced External Counterpulsation（EECP） on vascular endothelial function in hypertensive Patients.Methods Thirty-six hypertensive patients were randomly divided into 2 groups： the conventional therapeutics group（CT,n=20）,the＂conventional therapeutics＋EECP＂ group（CT＋EECP,n=16）.EECP was performed on CT＋EECP group,2 hours every other day lasting for 36 days.Endothelial dependent flow-mediated vasodilation（FMD） of the right brachial artery was assessed by day 0（prior to EECP） and day 36,respectively,immediately after EECP treatment.Plasma ET,Nitric oxide（NO） was measured at the same time points in all Patients.Results In CT＋EECP group,FMD were improved significantly [（7.90%±0.74%）,P0.01]after treatment,comparing to the CT group[（5.05%±1.19%）,P0.05].In CT＋EECP group NMD was improved significantly too（P0.05）.Level of Endothelin（ET） was significantly decreased in CT＋EECP group（60.21±20.38,P0.01）,comparing to the CT group[（73.69±22.13）mg/L,P0.05] after 36-day treatment.However,Level of Nitric oxide（NO） was significantly improved in CT＋EECP group（80.21±22.87,P0.01）,comparing to the CT group [（69.67±23.36） mg/L,P0.05]after treatment.Conclusion EECP could improve endothelial dysfunction in hypertensive patients.

关 键 词：增强型体外反搏 高血压 内皮细胞 血流介导的血管舒张功能 内皮素 一氧化氮 

分 类 号：R544.1[医药卫生—心血管疾病]