呋喃西林溶液制备方法改进及稳定性比较  

Improvement of preparation and the stability of furacillin solution

作　　者：栗志远[1] 王新红[1] 刘桂刚[1] 闫琼[1] 

机构地区：[1]解放军第22医院,青海格尔木816000

出　　处：《药学实践杂志》2010年第5期366-368,共3页Journal of Pharmaceutical Practice

摘　　要：目的改进呋喃西林溶液制备方法,观察其稳定性。方法对原处方的制备工艺加以改进,并通过留样观察对呋喃西林溶液进行定性分析和紫外分光光度法定量测定。结果改进法配制的呋喃西林溶液稳定性好,4个月内未析出沉淀,含量合格;原法配制的呋喃西林溶液2个月后析出红棕色沉淀,含量不合格。结论改进后的配制方法操作简单,溶液的稳定性提高,贮存期延长。Objective To improve the preparation method for furacillin solution and observe the stability of the solution. Methods The original preparation technics was modified. The furacillin solution was qualitatively analyzed by observation and quantitatively determined by UV speetrophotometry. Results The furacillin solution prepared in new method was proved to be stable in quality, without separating sediments in 4 months. However, sediment of furacillin solution prepared in old method was observed, color of the solution became deeper and content was out of quality 2 months later. Conclusion Improved method is convenient and feasible, which could increase the stability and ensure the safety and efficacy of furaeillin solution in clinical use.

关 键 词：呋喃西林溶液 制备方法 稳定性 

分 类 号：R943[医药卫生—药剂学]