2007～2009年我院抗感染药物的应用分析  

Analysis on utilization of anti-infection drugs in our hospital between 2007 and 2009

作　　者：杨啊晶[1] 杨宁[2] 张娟[1] 

机构地区：[1]北京大学医院,北京100871 [2]北京协和医学院中国医学科学院药物研究所,北京100050

出　　处：《药学实践杂志》2010年第5期374-377,共4页Journal of Pharmaceutical Practice

摘　　要：目的调查分析我院抗感染药物的使用情况,为临床合理用药和科学管理提供依据。方法用限定日剂量、用药频度和日治疗费用等客观指标分析药物利用的动态。结果 2007～2009年,头孢菌素类、喹诺酮类和大环内酯类药物名列抗感染药用药金额的前3位。头孢菌素类的头孢克洛、头孢呋辛、头孢氨苄、头孢哌酮/舒巴坦,以及喹诺酮类的左氧氟沙星和大环内酯类的罗红霉素、阿奇霉素和克拉霉素位于消耗金额排序前列。疗效确切、使用方便、不良反应少、价格便宜的一线抗感染药为主要用药,而且以口服制剂为主。常见致病菌的耐药率偏高,尤其对左氧氟沙星的耐药率最高达77.8%。结论我院抗感染药物的使用存在一定的不合理现象,仍需加强抗感染药物的应用管理。Objective To provide evidences for clinical rational use and scientific management of the anti-infection drugs through investigating the application status of the anti-infection drugs in our hospital . Methods Utilization of anti-infection drugs was analyzed by the index of DDD, DDDs and DDC. Results Cephalosporins, quinolones, macrolides ranked the top three on the consumption sum list of the anti-infection drugs between 2007 and 2009. Cefaclor, eefuroxime, cefalexin, cefopcrazone/sulbactam, levo- floxacin, roxithromycin, azithromycin and clarithromycin ranked the front rows on the consumption sum list. The most anti-infection drugs used in our hospital were the fist line drugs with certain effect, convenience for application, fewer adverse effect and cheaper price, moreover, mainly for oral administration. Resistance rates of common pathogenic bacteria were relatively high, especially to levofloxacin which had the highest rate of 77.8%. Conclusion The utilization of anti-infection drugs in our hospital was unreasonable in some respects. The application administration of anti-lnfection drugs still should be strengthened.

关 键 词：限定日剂量 用药频度 日治疗费用 抗感染药物 细菌耐药率 

分 类 号：R978.1[医药卫生—药品] R956[医药卫生—药学]