200例接种流感裂解疫苗安尔来福^(TM)安全性观察  

Observation on safety of influenzd virus split vaccine AnfluTM in 200 cases

作　　者：吴伟[1] 林新勤[2] 张静[2] 

机构地区：[1]合浦县疾病预防控制中心,广西北海536100 [2]南宁市疾病预防控制中心,广西南宁530011

出　　处：《中国热带医学》2010年第12期1497-1499,共3页China Tropical Medicine

摘　　要：目的评价流行性感冒(流感)裂解疫苗安尔来福TM(Influenzdvirus Split Vaccine,Inactivated;InfⅤ-sp)在儿童及未成年人中使用的安全性。方法对200名受试者进行流感裂解疫苗安尔来福接种后不良反应的临床观察,于接种疫苗后30min内和24、48、72h观察不良反应,直至不良反应消失。结果接种疫苗后不良反应发生率为11.0%,主要为轻度和中度反应。儿童组不良反应发生率为17.3%,未成年组不良反应发生率为4.2%。局部反应率为2.5%,全身反应发生率为10.5%,主要为发热、头痛、头晕、恶心、呕吐、腹痛及腹泻。结论本次的接种观察结果未见由疫苗引起新的不良反应,具有良好的临床安全性。Aim To evaluate the safety of an inactivated split influenza virus AnfluTM vaccine in infants and adolescents. Methods There 200 infants and adolescents were vaccinated with split influenza virus AnfluTM vaccine and the adverse reactions were observed 30 min,24,48 and 72h after vaccination until adverse reaction disappeared. Results The incidence of adverse reactions was 11.0% ,being 17.3% in infants and 4.2% in adolescents. Local and systemic reaction rates were 2.5% and 10.5% respectively,mainly fever,headache,dizziness,nausea,vomit,bellyache,diarrhea. Conclusion The split influenza virus AnfluTM vaccine is safe for preventive purpose.

关 键 词：流行性感冒裂解疫苗 安全性 不良反应 

分 类 号：R511[医药卫生—内科学]