阿托伐他汀对血管内皮功能及脑钠肽水平的影响  

The effects of atorvastatin on serum lipids, endothelial function in hyperlipidemic patient

作　　者：赵珂[1] 李晋宝[2] 

机构地区：[1]河南省三门峡市中心医院,472000 [2]河南省黄河三门峡医院药剂科

出　　处：《中国现代医药杂志》2010年第10期63-65,共3页Modern Medicine Journal of China

摘　　要：目的探讨高血压病患者接受阿托伐他汀强化治疗的调脂、非调脂作用及安全性。方法在我院确诊的高血压病同时具有高脂血症患者135例。采用饮食控制加阿托伐他汀10mg(A组,45例),20mg(B组,45例),40mg(C组,45例)。比较三组中血脂水平、血管内皮功能相关指标及脑钠肽水平。结果不同剂量阿托伐他汀治疗组(10mg、20mg、40mg)4周后血脂均下降但组间比较差异无显著性,均可改善内皮功能,其中C组4周后内皮功能相关指标一氧化氮(NO)水平明显高于A、B组(P<0.001),脑钠肽(BNP)水平明显低于A、B治疗组(P<0.001),血流介导的血管扩张(FMD)明显高于A、B组(P<0.001),不良反应三组相似。结论降脂治疗可改善内皮功能,40mg阿托伐他汀强化降脂治疗改善内皮功能及脑钠肽水平下降明显。Objective To assess the safety and effect on lipid-lowering and endothelial function by treatment with atorvastatin.Methods 135 hyperlipidemic patients were signed disorder lipidemic group.The disorder lipidemic group was given atorvastatin 10mg qd,20mg qd or 40mg qd.The total period of treatment was 4 weeks.TC,TG,LDL-C,HDL-C,NO,BNP,FMD were determind in disorder lipidemic group of pretreatment and treatment after 4 weeks.Results TC,TG,LDL-C,FIB were decreased significantly （P〈0.01）in atorvastatin 40mg qd group after 4 weeks.BNP was decreased significantly （P 0.05）in atorvastatin 40mg.NO,FMD were increased significantly （P〈0.01） in atorvastatin 40mg qd group.Conclusion Both atorvastain doses significantly reduced lipid and improved endothelial function.High doses atorvastatin has better effect in controling lipid and improved endothelial function.

关 键 词：高血压 阿托伐他汀 一氧化氮 脑钠肽 流量依赖性扩张功能 

分 类 号：R544.1[医药卫生—心血管疾病]