重组人表皮生长因子不同剂型作用于糖尿病溃疡动物模型的疗效比较  

Compare the curative effect of different pharmaceutical of recombinant human epidermal growth factor on animal model of diabetes ulcers

作　　者：安宏元[1] 陈杰翔[2] 

机构地区：[1]吉林省柳河县人民医院内分泌科,135300 [2]四川省泸州医学院附属医院泌尿外科

出　　处：《中国现代医药杂志》2010年第10期82-85,共4页Modern Medicine Journal of China

摘　　要：目的比较重组人表皮生长因子(rhEGF)不同剂型作用于糖尿病溃疡动物模型创面的疗效差别。方法建立糖尿病溃疡动物模型,将模型随机分为重组人表皮生长因子水剂组和重组人表皮生长因子凝胶组,动态观察重组人表皮生长因子水剂组和重组人表皮生长因子凝胶组对溃疡面积、愈合时间及动态愈合率的影响。结果重组人表皮生长因子凝胶组在溃疡的面积变化、愈合时间及动态愈合率方面均较重组人表皮生长因子水剂组差异有显著性意义(P<0.01)。结论重组人表皮生长因子凝胶比重组人表皮生长因子水剂更能促进糖尿病溃疡创面的愈合。Objective To compare the effect of different pharmaceutical of recombinant human epidermal growth factor on animal model of diabetes ulcers.Methods To establish the animal model of diabetes ulcers.These animal models were randomly divided into rhEGF aqueous pharmaceutical group and rhEGF gel group.The healing area of the ulcer ,healing time of the ulcer and healing rate of the ulcer were compared the deferent effect in rhEGF aqueous pharmaceutical group and rhEGF gel group.Results The effect of rhEGF gel group was better than the effect of rhEGF aqueous pharmaceutical group in healing area of the ulcer ,healing time of the ulcer and healing rate of the ulcer by investigated （P〈0.01）.Conclusion rhEGF gel can promote healing of diabetes mellitus better than rhEGF aqueous pharmaceutical.

关 键 词：糖尿病溃疡 模型 重组人表皮生长因子凝胶 

分 类 号：R587.1[医药卫生—内分泌]