8-异前列腺素F_(2α)在高原地区老年慢性肺心病发病中的作用和临床意义  

Effects of 8-iso prostaglandin F_(2α) on elderly patients with chronic cor pulmonale in high altitude areas and its clinical significance

作　　者：杨生岳[1] 冯恩志[1] 郭振援[1] 黄宁侠[1] 张瑛[1] 陈宗茹[1] 张爱军[1] 种银侠[1] 

机构地区：[1]解放军第四医院兰州军区呼吸内科中心,西宁810014

出　　处：《中华肺部疾病杂志（电子版）》2010年第4期18-20,共3页Chinese Journal of Lung Diseases(Electronic Edition)

摘　　要：目的探讨8-异前列腺素F2α(8-iso PGF2α)在高原地区慢性肺心病(HAECCP)老年患者发病中的作用和临床意义。方法选取HAECCP急性加重期老年患者62例,缓解期患者58例,另选40例健康体检者作为正常对照组,分别测定血清8-iso PGF2α、1秒钟用力呼气容积(FEV1)占预计值的百分比(FEV1%)、FEV1/用力肺活量(FVC)比值(FEV1/FVC)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)。结果 HAECCP急性加重期血清8-iso PGF2α[(9.56±1.94)μg/L]显著高于缓解期[(7.22±1.78)μg/L]和健康对照组[(4.93±1.31)μg/L](均P<0.01),缓解期显著高于健康对照组(均P<0.01)。HAECCP急性加重期和缓解期血清8-iso PGF2α与FEV1%、FEV1/FVC、PaO2均呈显著负相关(分别r=-0.586、-0.578、-0.625和r=-0.563、-0.582、-0.657,均P<0.01),与PaCO2呈显著正相关(r=0.674、0.695,均P<0.01)。结论 HAECCP老年患者血清8-iso PGF2α增高与病情严重程度有关,血清8-iso PGF2α可作为检测HAECCP老年患者气道氧化应激的客观指标。Objective To investigate the effects and clinical significance of 8-iso prostaglandin （PG） F2α （8-iso PGF2α） in elderly patients with chronic eor pulmonale in high altitude areas （HAECCP）. Methods Level of serum 8-iso PGF2α, forced expiratory volume in one second（ FEVl ） , expressed as percentage predicted（ FEV1% ）, ratio of FEV1 to forced vital capacity（ FEV1/FVC） , partial pressure of arterial 02 （ PaO2 ） and partial pressure of arterial CO2 （ PaCO2 ） were measured in 62 patients with HAECCP in the acute exacerbation stage, 59 patients with HAECCP in the remission stage and 40 normal control subjects. Results Level of serum 8-iso PGF2α [ （9.56 ± 1.94） μg/L] in the patients with HAECCP in acute exacerbation stage was significantly higher than that in the patients with HAECCP in the remission stage[ （7.22 ± 1.78）μg/L] and in normal control subjects[ （4.93 ± 1.31 ） μg/L] （all P 〈0.01 ）, level of serum 8-iso PGF2αin the patients with HAECCP in the remission stage was significantly higher than that in normal control subjects（ all P 〈0. O1 ）. Level of serum 8-iso PGF2α in the patients with HAECCP in acute exacerbation and remission stage was negatively correlated with FEV1%, FEV1/FVC, PaO2 （r = - 0.586, - 0.578, - 0.625 and r = - 0. 563, - 0.582, - 0. 657, respectively, all P 〈 0. O1 ）, positively correlated with PaCO2 （r = 0. 674, 0.695, all P 〈 0.01 ）. Conclusion 8-iso PGF2α levels in serum were associated with the severty of HAECCP, implicating 8-iso PGF2α may be useful in monitoring airway oxidative stress in HAECCP.

关 键 词：肺疾病 阻塞性 肺心病 异前列腺素 高原 

分 类 号：R563[医药卫生—呼吸系统]