益气强心饮对慢性心衰大鼠心肌细胞凋亡及Fas FasL基因蛋白表达影响的实验研究  

Yiqi Qiangxi Drink for Chronic Heart Failure Rats Myocardial Cell Apoptosis and Fas FasL Gene Experimental Study of Protein Expression

作　　者：董波[1] 宋婷婷[1] 董天宝[1] 王东海[1] 

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《中华中医药学刊》2010年第10期2075-2077,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省卫生厅-辽宁省医学重点专科建设项目(辽卫函字[2007]499)

摘　　要：目的:本实验旨在通过动物实验观测中药益气强心饮对慢性心衰大鼠细胞凋亡及Fas、FasL基因蛋白表达的影响。材料与方法:采用腹主动脉缩窄法结合皮质激素造模法建立慢性心衰阳虚水泛证大鼠模型,随机分为模型组、西药对照组、中药对照组、中药低剂量组、中药中剂量组、中药高剂量组、假手术组,用药8周后,观察各组大鼠的心肌细胞凋亡及Fas、FasL基因蛋白表达。结果:益气强心饮能明显下调慢性心衰大鼠心肌组织Fas、FasL基因蛋白表达,疗效等同西药对照组。结论:益气强心饮可调控慢性心衰大鼠的心肌细胞凋亡,具有治疗及延缓心衰的发展等作用。Objective：This study was designed by observing Yiqi Qiangxin Drink animals with chronic heart failure on myocardial apoptosis,and Fas,FasL protein expression.Methods：Abdominal aortic coarota deficiency rats were randomly divided into model group,comparison group,control group of Chinese medicine,Chinese medicine low dose group Chinese herbal medicine dose group,Chinese high-dose group,sham operation group,After 8 weeks of treatment,rats of myocardial apoptosis and Fas,FasL gene expression.Results：Yiqi Qiangxin Drink significantly reduced myocardial tissue of rats with chronic heart failure Fas,FasL protein expression,effect the same comparison group.Conclusion：Yiqi Qiangxin Drink chronic heart failure can be regulated cardiomyocyte apoptosls in rats with heart failure treatment and delay the development of the role.

关 键 词：慢性心力衰竭 益气强心饮 细胞凋亡 FAS/FASL 

分 类 号：R285.5[医药卫生—中药学]