尼古丁对大鼠局灶性脑缺血再灌注损伤的神经保护作用  

The neuroprotection of nicotine to the cerebral ischemia/reperfusion injury of rats

作　　者：陈宇[1] 桑韩飞[1] 马丽[1] 霍婷婷[1] 熊利泽[1] 

机构地区：[1]第四军医大学西京医院麻醉科,西安710032

出　　处：《神经解剖学杂志》2010年第5期465-469,共5页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金杰出青年科学基金(30725039);国家自然科学基金青年科学基金(30600610)

摘　　要：目的:研究尼古丁对大鼠局灶性脑缺血再灌注损伤是否具有神经保护作用。方法:在大鼠大脑中动脉堵塞(MCAO)前30min给予腹腔注射尼古丁酒石酸盐溶液,观察局灶性脑缺血2h再灌注24h后,大鼠神经行为学评分及脑梗死容积的变化。结果:再灌注24h后,与单纯缺血再灌注组相比,给予尼古丁酒石酸盐溶液注射可以改善动物的神经行为学评分、减少脑梗死容积百分比(P<0.05)。结论:尼古丁对大鼠局灶性脑缺血再灌注损伤具有神经保护作用。Objective：To explore whether nicotine has a neuroprotective effect on the focal cerebral ischemia/reperfusion（I/R）injury in rats.Methods：Thirty min after the injection of nicotine ditartrate,focal cerebral ischemia was induced by middle cerebral artery occlusion（MCAO）for 120 min in male Sprague-Dawley rats.The neurobehavioral scores,infarct volumes were evaluated at 24 h of reperfusion.Results：After 24 h of reperfusion,nicotine ditartrate injection improved neurological outcome and reduced infarct size（P〈0.05）.Conclusion：These results suggest that nicotine can have neuroprotection against I/R injury.

关 键 词：尼古丁 局灶性脑缺血再灌注 神经保护 大鼠 

分 类 号：R965[医药卫生—药理学]