基于最大长序列刺激的听觉诱发反应信噪比分析与仿真  

Analysis and Simulation of Signal to Noise Ratio of Auditory Evoked Potentials Based on Stimulation with Maximum Length Sequence

作　　者：苏园园[1] 王涛[1] 李彬[1] 

机构地区：[1]南方医科大学生物医学工程学院,广东广州510515

出　　处：《航天医学与医学工程》2010年第5期335-339,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金资助项目(60771035)

摘　　要：目的提出应用MLS方法后反应信噪比的变化公式,探讨不同阶数序列、刺激率和噪声条件下,最大长序列阶数和刺激率等参数与听觉诱发反应信噪比变化和还原质量的关系,并验证推导的理论公式。方法通过仿真实验,还原不同刺激参数和噪声环境下的听觉诱发反应,并讨论其信噪比的变化情况。结果在噪声环境和刺激率不变的情况下,信噪比的提高与阶数成正比;在噪声环境和阶数不变的情况下,信噪比的变化与刺激率成反比。结论在已知反应先验知识的情况下,本文提出的理论公式可较为准确地估计还原反应的信噪比变化情况,为不同实验条件下的最大长序列提供选择依据,并可为高刺激率下听觉诱发反应及听觉系统的适应性问题的研究提供实验设计参考。Objective To propose and verify a formula for signal to noise ratio （SNR） changes of auditory e- voked potential （AEP） elicited by maximum length sequence （MLS） and discuss the recovery quality and the SNR changes of MLS-AEP obtained in different experimental conditions. Methods AEPs evoked by 4 - 7 order MLS were recovered at different high stimulus rates and under simulated noise environment, and their SNR changes were analyzed. Results SNR change was proportional to MLS order with certain noise environment and stimulus rates, while it was inversely proportional to stimulus rates by keeping the same noise environment and MLS order. Conclusion With prior knowledge, the SNR changes of MLS-AEP can be estimated accurately u- sing the proposed formula. It is helpful to provide reference for MLS selection under different experimental conditions, as well as the research on high stimulus rate evoked AEP and the adaptation of auditory system.

关 键 词：听觉诱发反应 最大长序列 信噪比 

分 类 号：R318[医药卫生—生物医学工程] TP391[医药卫生—基础医学]