Lipid-laden dendritic cells fail to function  

作　　者：Philip C Calder 

机构地区：[1]Institute of Human Nutrition and Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Institute of Developmental Sciences Building, MP887 Southampton General Hospital, Tremona Road, Southampton S016 6YD, United Kingdom

出　　处：《Cell Research》2010年第10期1089-1091,共3页细胞研究（英文版）

摘　　要：Dendritic cells （DCs） are professional antigen-acquiring, -processing and -presenting cells [1-4] . As such, DCs form the key link between the innate and acquired immune responses playing a role in host defence and in immune tolerance [1-4]. Accordingly, defects in the ability of DCs to function can lead to increased susceptibility to infection, loss of tolerance, autoimmunity and turnout growth [1-4]. Sub-classes of DCs are defined and discriminated by the expression of different cell surface markers. Identification of factors that affect the activation or function of DCs is important in increasing our understanding of how these cells are regulated physiologically and of how they may become impaired leading to pathological conditions. Furthermore,

关 键 词：树突状细胞 脂质 免疫耐受 免疫反应 宿主防御 生长缺陷 细胞表面 生理调节 

分 类 号：S858.21[农业科学—临床兽医学] Q25[农业科学—兽医学]