Effects of human mesenchymal stem cell transplantation in the bilateral corpus striatum in a rat model of Tourette's syndrome  

作　　者：Xiumei Liu Yuwei Wang Mingji Yi 

机构地区：[1]Department of Pediatrics,Yantai Yuhuangding Hospital,Qingdao Medical University,Yantai 264000,Shandong Province,China [2]Department of Pediatrics,Qilu Hospital of Shandong University,Jinan 250012,Shandong Province,China [3]Department of Child Health Care,Affiliated Hospital of Medical College of Qingdao University,Qingdao 266021,Shandong Province,China

出　　处：《Neural Regeneration Research》2010年第17期1285-1290,共6页中国神经再生研究（英文版）

摘　　要：Tourette＇s syndrome is treated by behavioral or pharmacological therapy.However,patients with malignant Tourette＇s syndrome also exhibit life-threatening symptoms,which are unresponsive to conservative treatments or neurosurgical procedures,such as deep brain stimulation.In recent years,mesenchymal stem cells（MSCs）have shown therapeutic potential in many neurological diseases.Therefore,the present study proposed to use MSC transplantation as a novel therapy for Tourette＇s syndrome.Stereotypic behaviors in Tourette＇s syndrome rats decreased significantly at21 days after human MSCs transplantation into the striatum.Immunohistochemistry analyses revealed survival of transplanted human MSCs and differentiation into neurons and astrocytes in the rat brain.Results suggest that intrastriatal transplantation of human MSCs could provide therapeutic potential for Tourette＇s syndrome.Tourette＇s syndrome is treated by behavioral or pharmacological therapy.However,patients with malignant Tourette＇s syndrome also exhibit life-threatening symptoms,which are unresponsive to conservative treatments or neurosurgical procedures,such as deep brain stimulation.In recent years,mesenchymal stem cells（MSCs）have shown therapeutic potential in many neurological diseases.Therefore,the present study proposed to use MSC transplantation as a novel therapy for Tourette＇s syndrome.Stereotypic behaviors in Tourette＇s syndrome rats decreased significantly at21 days after human MSCs transplantation into the striatum.Immunohistochemistry analyses revealed survival of transplanted human MSCs and differentiation into neurons and astrocytes in the rat brain.Results suggest that intrastriatal transplantation of human MSCs could provide therapeutic potential for Tourette＇s syndrome.

关 键 词：Tourette＇s syndrome STEREOTYPY animal model mesenchymal stem cells TRANSPLANTATION neural regeneration 

分 类 号：Q813[生物学—生物工程] S827.36[农业科学—畜牧学]