痰中SP-D水平的改变在肺结核诊断中的价值探讨  

Value of SP-D levels in the sputum in the diagnosis of pulmonary tuberculosis

作　　者：胡华[1] 徐勇[1] 迟晶宇[1] 鞠云飞[1] 杨燕[1] 侯宝青[1] 李学政[1] 孟繁敏[1] 李磊[1] 

机构地区：[1]山东省胸科医院呼吸科,济南250013

出　　处：《山东大学学报（医学版）》2010年第9期79-81,共3页Journal of Shandong University:Health Sciences

基　　金：山东省科学技术厅基金资助项目(2006GG2202035)

摘　　要：目的检测肺结核患者痰中肺表面活性物质相关蛋白D(SP-D)的水平及其变化,探讨其对肺结核诊断和鉴别诊断的价值。方法采用ELISA方法检测100例肺结核患者、84例健康人痰中SP-D的水平及抗结核菌抗体,采用沉降法检测血沉,采用电阻法测定白细胞计数、中性粒细胞及淋巴细胞比例,采用Mantoux法进行PPD实验。结果肺结核患者痰中SP-D的水平明显低于健康人(P<0.05),性别、年龄等因素对肺结核患者的SP-D水平没有明显影响(P>0.05)。结论测定痰中SP-D的水平对于肺结核的诊断和鉴别诊断具有参考价值。Objective To observe the level of surfactant protein-D（SP-D） in the sputum in pulmonary tuberculosis patients,and explore its value in the diagnosis of pulmonary tuberculosis.Methods The SP-D level in the sputum was de-tected by ELISA in 100 samples from pulmonary tuberculosis patients and 84 samples from healthy subjects.The leucocyte count,neutrophilic granulocyte percentage and lymphocyte percentage were determined with the electric resistance meth-od,erythrocyte sedimentation rates by the sedimentation process,and tubercle bacillus antibodies by ELISA.The PPD tri-al was executed with the Mantoux method.Results Level of SP-D in the sputum in pulmonary tuberculosis was much lower than that in healthy subjects（P0.05） ,and there was no obvious difference between pulmonary tuberculosis patients with different genders,ages and other factors （P0.05） .Conclusions Detection of SP-D in the sputum is of great value in the diagnosis and differential diagnosis of pulmonary tuberculosis.The gender,age and other factors have nothing to do with the level of SP-D in the sputum in pulmonary tuberculosis.

关 键 词：结核 肺 痰 诊断 肺表面活性物质相关蛋白D 

分 类 号：R521[医药卫生—内科学]