牛痘疫苗致炎兔皮提取物治疗带状疱疹后神经痛的疗效评价  

Evaluation of therapeutic efficiency of analgecine injection on postherpetic neuralgia

作　　者：张国转[1] 梁立双[1] 于少华[2] 刘旭东[1] 

机构地区：[1]山东大学齐鲁医院疼痛科,济南250012 [2]山东大学校医院,济南250012

出　　处：《山东大学学报（医学版）》2010年第9期107-109,共3页Journal of Shandong University:Health Sciences

摘　　要：目的评价牛痘疫苗致炎兔皮提取物治疗带状疱疹后遗神经痛(PHN)的临床效果。方法带状疱疹后遗神经痛患者87例,随机分为A、B两组,A组为对照组,给予常规的止痛、营养神经、理疗等综合治疗,B组在A组治疗方案的基础上给予牛痘疫苗致炎兔皮提取物3.6IU/次,bid,im,共15d。分别于就诊时(T0)、治疗7d(T1)、半月(T2)、1月(T3)时利用视觉模拟评分法评估两组病例的疼痛缓解程度、睡眠质量评估生活质量提高程度,并观察其不良反应。结果视觉模拟评分及睡眠质量评估结果:治疗后,A、B两组较治疗前均显著改善(P<0.01),B组治疗后随时间延长,疼痛缓解程度及睡眠质量改善越显著,各时间段均优于A组。且与A组相比,B组并未出现恩再适所致的过敏、肝损害等不良反应。结论牛痘疫苗致炎兔皮提取物可明显地减轻PHN患者疼痛、改善睡眠,提高生活质量,起效快,效果明显,且安全性好。Objective To estimate the effectiveness of analgecine injection on postherpetic neuralgia（PHN） .Methods A total of 87 elderly outpatients suffering from PHN were enrolled.All patients aged more than 60 years were randomly di-vided into group A and group B：patients in group A were treated with conventional therapy,including analgesia,neurotro-phic,and physical therapies,whereas patients in group B were given additional 3.6 IU of analgecine twice daily for 15 days.All patients were tested by VAS and QS when treated （T0） and followed-up for 7 days（T1） ,15days（T2） ,and 1 month（T3） .Results Scores of VAS and QS in group A and group B were significantly ameliorated compared with those before treatment （P0.01） .As time went on,there was a more significant amelioration in group B than that in group A.Compared with group A,there was no side effect related with analgecine injection in group B,such as hepatic lesion and anaphylactic reactions.Conclusion Analgecine injection can rapidly and significantly alleviate the dispersion of pain and improve the QS of the patients with PHN.Analgecine injection is effective and safe in the treatment of PHN.

关 键 词：带状疱疹后神经痛 牛痘疫苗致炎兔皮提取物 视觉模拟评分 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]