LADA患者胰岛β细胞功能及血清白介素6、肿瘤坏死因子α水平变化的探讨  

The change of islet β-cell function and serum IL-6,TNF-α levels in LADA patients

作　　者：张立莹[1] 孟作龙[1] 周颖[1] 赵艳[1] 

机构地区：[1]兰州大学附属白银医院内分泌科,甘肃白银730900

出　　处：《中国糖尿病杂志》2010年第10期749-751,共3页Chinese Journal of Diabetes

摘　　要：目的观察成人隐匿性自身免疫性糖尿病(LADA)患者胰岛β细胞功能及血清白介素6(IL-6)和肿瘤坏死因子α(TNF-α)水平的变化,探讨细胞因子在LADA发病中的作用。方法分别测定LADA患者32例、2型糖尿病(T2DM)患者30例、健康人(NC)30名的血清胰岛素(Ins)、C-肽(C-P)和IL-6、TNF-α的水平。结果 LADA组空腹、餐后Ins和C-P均明显低于T2DM组(P<0.01或P<0.05);NC组、T2DM组、LADA组的IL-6和TNF-α水平依次增高(P<0.05或P<0.01)。结论 LADA患者的胰岛β细胞功能损伤比T2DM患者严重。IL-6、TNF-α可能参与了LADA的自身免疫过程及T2DM的免疫炎症过程。Objective To observe the changes in islet cell function and serum IL-6, TNF-α levels of latent autoimmune diabetes in adults （LADA） and the effect of the cytokines on the pathogenesis of LADA. Methods 32 LADA patients,30 type 2 diabetic patients and 30 healthy subjects underwent the detections of serum insulin, C-peptide, IL-6, and TNF-α. Results Serum level of fasting and postprandial insulin and C-peptide were lower in LADA than in type 2 diabetes （P〈0.05 or P〈0. 01）. The serum IL-6 and TNF-α levels were gradually higher one by one in three groups of healthy subjects, T2DM and LADA. Conclusions The β-cell function damage is more serious in LADA than in type 2 diabetes. IL-6, TNF-α may be involved in the LADA autoimmune process and in the immune inflammatory process of type 2 diabetes.

关 键 词：白介素 肿瘤坏死因子 胰岛素 C-肽 成人隐匿性自身免疫性糖尿病 

分 类 号：R587.1[医药卫生—内分泌]