2型糖尿病患者脉搏波速度的变化及其影响因素  

Changes of pulse wave velocity and its influential factors in patients with type 2 diabetes

作　　者：王晓玉[1,2] 刘永铭[1] 周新人[1] 王建伟[1] 杨京港[1] 

机构地区：[1]兰州大学第一医院老年科,730000 [2]江苏省连云港市第一人民医院东方医院海港内一科

出　　处：《中国糖尿病杂志》2010年第10期767-769,共3页Chinese Journal of Diabetes

摘　　要：目的探讨2型糖尿病患者脉搏波速度的变化及其影响因素。方法选择2型糖尿病患者(T2DM组)48例和健康体检者(NC组)22名,进行颈股动脉脉搏波速度(CF-PWV)、颈-桡动脉脉搏波速度(CR-PWV)、颈-足背动脉脉搏波速度(CD-PWV)的测量。结果 2型糖尿病患者CF-PWV高于NC组;伴有合并症或/和并发症者CF-PWV升高更为显著,年龄、SBP、脉压差、糖尿病病程、尿白蛋白排泄率(UAER)、眼底病变与CF-PWV呈正相关,其中年龄和UAER是PWV的独立预测因素。结论 2型糖尿病中心动脉弹性减低,年龄、SBP、脉压差、糖尿病病程、UAER、眼底病变与中心动脉弹性减低有关。Objective To study the changes of pulse wave velocity（PWV）and its influential factors in the patients with type 2 diabetes. Methods 48 diabetic patients and 22 healthy people were enrolled in this study. Automatic PWV measuring system was applied to examine carotid-femoral PWV （CF-PWV）, carotid-radial PWV （CR-PWV） and carotid-dorsum of foot PWV（CD-PWV）. Results Compared with the control group, CF-PWV of the diabetic patients was significantly increased （P〈0.05）, and was correlated with age, systolic blood pressure, pulse pressure, diabetic course, UAER and diabetic retinopathy（r= 0. 57 , 0. 38 , 0. 51, 0. 44 , 0. 449,0. 319;all P〈0.05 respectively）, among which age（P〈 0.05） and UAER（P〈0.05） were independent predictors of CF-PWV. The CD-PWV was increased only in the patients with complications, and no statistical difference in CR-PWV was showed among the groups. Conclusions The elasticity of central elastic large artery, which is associated with age, systolic blood pressure, pulse pressure, diabetic course, UAER and diabetic retinopathy, is decreased in type 2 diabetics.

关 键 词：糖尿病 2型 脉搏波速度 动脉僵硬度 

分 类 号：R587.1[医药卫生—内分泌]