胚胎晚期母体暴露LPS对子代中年CD-1子鼠背海马Synaptotagmin Ⅰ含量的影响  

Effects of maternal exposure to lipopolysaccharide during late pregnancy on synaptotagmin Ⅰlevel in dorsal hippocampus of middle-aged offspring CD-1 mice

作　　者：尹廷伟[1] 陈贵海[1] 杨启纲[1] 王龙海[1] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《安徽农业大学学报》2010年第4期614-616,共3页Journal of Anhui Agricultural University

基　　金：安徽省高校省级自然科学研究重大项目(ID2008007-1)资助

摘　　要：探讨胚胎晚期母体暴露细菌脂多糖(LPS)对中年CD-1子鼠背海马突触前囊泡蛋白synaptotagmin Ⅰ(Syt Ⅰ)含量的影响。结果表明Syt Ⅰ蛋白在CD-1子鼠背海马DG、CA1和CA3区均有表达,胚胎晚期母体暴露LPS后的中年CD-1子鼠较同年龄对照组海马各区Syt Ⅰ含量显著增高。这些结果提示胚胎晚期母体暴露LPS可增加CD-1子鼠中年时背海马Syt Ⅰ含量。The effect of maternal exposure to LPS（lipopolysaccharide） during late pregnancy on the content of synaptotagmin Ⅰ in dorsal hippocampus in middle-aged offspring CD-1 mice was explored.The results showed that the expression of synaptotagmin Ⅰ could be detected in the DG,CA3 and CA1 subareas of dorsal hippocampus of the CD-1 mice.The relative amount of synaptotagmin Ⅰ shown by histoimmunochemical method in the LPS-treated group was significantly higher than that in the control group.The results suggest that maternal exposure to LPS during late pregnancy significantly increase the content of synaptotagmin Ⅰ in dorsal hippocampus of middle-aged offspring CD-1 mice.

关 键 词：衰老 细菌脂多糖 海马 小鼠 SYNAPTOTAGMIN Ⅰ 

分 类 号：R338.6[医药卫生—人体生理学] R-332[医药卫生—基础医学]