质粒介导喹诺酮类耐药机制研究进展  

Development of Plasmid Mediated Quinolone Resistance Genes

作　　者：朱恒乾[1] 彭斌 廖晓萍[1] 

机构地区：[1]华南农业大学兽医学院广东省兽药研制与安全评价重点实验室,广州510642 [2]湖南省桑植县动物防疫监督管理局,桑植427100

出　　处：《中国畜牧兽医》2010年第10期81-86,共6页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金-广东省政府自然科学基金联合基金重点项目(U0631006);国家自然基金(30800836)

摘　　要：质粒介导喹诺酮类耐药(PMQR)基因的出现,迅速提高了细菌对喹诺酮类药物的耐药性,给临床细菌性疾病的治疗带来了严重的威胁。目前虽然认为喹诺酮类耐药基因(qnr)只引起低水平耐药,但低水平耐药性可使细菌数量达到出现突变所需的浓度,从而出现高水平耐药。因此,对质粒介导该类药物耐药机制的研究,及耐药基因的分子传播机制的研究不仅能指导临床合理用药,而且有助于控制耐药菌株的产生和传播。Bacterial resistance to quinolone drugs was improved rapidly with the appearance of plasmid-mediated quinolone resistance（PMQR） genes,and which bring about serious threat to clinical therapy.Currently,we know that quinolone resistance genes（qnr） conferred low-level resistance to quinolone drugs,but this low-level resistance may cause the quantity of bacterial overrun of mutant prevention concentration,and which may lead to high-level resistance to quinolones.Therefore,investigations of plasmid mediated drug resistance to quinolones as well as mechanisms of dissemination of resistance genes in molecular level are not only useful to guide clinical therapy,but also help to control the production and dissemination of resistant strains.

关 键 词：PMQR 耐药 QNR 喹诺酮 

分 类 号：S859.7[农业科学—临床兽医学]