便携式加压舱治疗急性一氧化碳中毒大鼠的疗效研究  

Effect of portable compression chamber on acute carbon monoxide poisoning： experiment with rats

作　　者：李明 韩梅 郑彦茹 范彦军 梁喜凤 马瑞凤 刘琼 楚若鹏[2] 王文举 张宏顺[3] 孙承业[3] 

机构地区：[1]石家庄市急救中心,河北050011 [2]石家庄市第一医院ICU [3]中国疾病预防控制中心职业卫生与中毒控制所

出　　处：《中国急救复苏与灾害医学杂志》2010年第10期903-905,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：卫生行业科研专项项目（200802020）

摘　　要：目的 评价便携式加压舱在治疗大鼠急性一氧化碳中毒中的疗效.方法 72只大鼠分成5组：A组（空门组）、B组（对照组）、C组（常压高氧组）、D组（加压高氧组）和E组（加压纯氧组）.除对照组外,其余各组均给予腹腔注射纯品CO气体（体积分数99.95%）,剂量0.15 ml/g,达到染毒状态后放入加压舱中给予不同条件的氧疗.治疗后应用血气分析仪行血气分析,测定动脉血氧分压（PO2）、碳氧血红蛋白（COHb）.结果 实验各组的PO2值均显著低于空白组（A组）,且相比较有显著差异（P〈0.0001）.E组有效的恢复了PO2值,其中E2组最有效,将PO2值恢复至正常值的74%（P〈0.05）;实验各组的COHb值均显著高于空白组（A组）,且相比较有显著差异（P〈0.001）.E组、D组和C组均有效的减低了COHb值,其中E2最有效,将COHb值减低了19%（P〈0.05）.结论 应用便携式加压舱并给予纯氧治疗,能够很好的提高ACMP大鼠的PO2值,并降低COHb值,疗效优于常规氧疗方式.Objective To evaluate the therapeutic effects of portable compression chamber on acute carbon monoxide poisoning （ACMP）. Methods Eight rats undergoing none treatment were used as blank control group （Group A）. Other 64 rats underwent intraperitoneal injection of pure CO to establish ACMP models and 12 min later were randomly divided into 4 equal groups： Group B put in natural environment with normal air pressure for 60 rain （Group B1, n=8） or 90 min （Group B2, n=8）： Group C undergoing oxygen therapy in compression chamber with 1.0 atmospheric pressure plus 50% oxygen for 60 rain （Group C1, n=8） or 90 rain （Group C2, n=8）; Group D undergoing oxygen therapy in compression chamber with 1.3 atmospheric pressures and 38.5% oxygen for 60 min （Group D1, n=8） or 90 rain （Group D2, n=8）; and Group E undergoing oxygen therapy in compression chamber with 1.3 atmospheric pressures and 100% oxygen for 60 min （Group El, n=8） or 90 rain （Group E2, n=8）. By the end of experiment blood samples were collected from the abdominal arteries to examine the arterial partial pressure of oxygen （PO2） and carbonyl hemoglobin （COHb）. Results The PO2 values of all experimental groups were all significantly lower than that of the blank control group （all P〈0.0001）. The higher the oxygen concentration used and the longer the treatment time the higher the PO2 values. The COHb of all experimental groups were all significantly higher than that of the blank control group （all P〈0.001）. The higher the oxygen concentration used and the longer the treatment time the lower the COHb level. Conclusion Portable compression chamber is effective in treatment of AMCP.

关 键 词：便携式加压舱 急性一氧化碳中毒 动脉血氧分压 碳氧血红蛋白 

分 类 号：R595.1[医药卫生—内科学]