尾加压素Ⅱ与原发性高血压关系的研究  

Effect of Urotensin Ⅱ on the progress of primary hypertension

作　　者：何丹[1] 杜婧[1] 景莉玲[1] 李芳[1] 白洁[1] 刘华[1] 陈更业[1] 

机构地区：[1]宁夏自治区人民医院,宁夏银川750021

出　　处：《宁夏医学杂志》2010年第10期901-902,共2页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(2006-CA-018)

摘　　要：目的探讨尾加压素Ⅱ(U-Ⅱ)是否参与了原发性高血压的发病机制。方法选择原发性高血压患者(高血压组,n=90)和正常人(对照组,n=30),用放射免疫法测定血浆U-Ⅱ的水平,研究原发性高血压对患者的U-Ⅱ的影响。结果对照组与1级高血压组相比,差异无统计学意义;高血压组各级组间U-Ⅱ水平差异有统计学意义(P<0.05);正常组、1级、2级、3级高血压组的U-Ⅱ水平分别为7.23±0.99、7.52±1.01、8.15±0.89、8.99±0.98pg/m l,有显著相关性(r系数分别为0.83、0.78、0.80,P<0.05)。结论 U-Ⅱ可能与原发性高血压的发生发展及高血压的分级呈正相关。Objective To investigate whether Urotensin Ⅱ promotes the progress of primary hypertension.Methods Radioimmuno assay was used to measure the plasma U-Ⅱ in 90 patients with primary hypertension and 30 normal persons.Results There was no correlation between the normal group and hypertension of stageⅠ,but the significant correlation of patients with hypertension in interclass（P﹤0.05）.The level of UⅡ in normal group,the one with hypertension of stage Ⅰ,stageⅡ and stage Ⅲwere 7.23±0.99 pg/ml,7.52±1.01 pg/rnl,8.15±0.89 pg/ml and 8.99±0.98 pg/ml,respectively.It was significantly correlated with UⅡ（r=0.83,r=0.78 and r=0.80,P〈0.005）.Conclusion It is positive correlation between the occurrence and development of hypertension and U-Ⅱraised in some patients with hypertension.

关 键 词：尾加压素Ⅱ 原发性高血压 放射免疫法 

分 类 号：R544.1[医药卫生—心血管疾病]