早期应用替罗非班对急性STEMI行经皮冠状动脉介入的疗效观察  

Effects of early use of Tirofiban of percutaneous coronary intervention in patients with st-segment elevation myocardial infarction

作　　者：李国境 魏宁[2] 才江平 

机构地区：[1]宁夏煤炭总医院汝箕沟医院,宁夏石嘴山753404 [2]宁夏医科大学附属医院,宁夏银川750004 [3]宁夏武警总队医院,宁夏银川750004

出　　处：《宁夏医学杂志》2010年第10期910-911,共2页Ningxia Medical Journal

摘　　要：目的观察早期应用替罗非班对急性ST段抬高心肌梗死(STEM I)急诊行经皮冠状动脉介入治疗(PC I)及梗死相关血管的血流及梗死区心肌灌注的影响。方法将160例发病<12h急诊行PC I的急性STEM I患者分为PC I前早期应用组及PC I前即刻应用组,各80例。观察两组PC I前后心肌梗死溶栓(TIM I)分级及梗死区心肌灌注(TMP)分级,观察PC I后30d主要心血管事件(MACE)及术后出血发生情况。结果早期应用组PC I前TIM I 3级及TMP 3级的获得率分别为31.3%、33.8%;PC I后TIM I 3级及TMP 3级分别为92.5%、75.0%;两组PC I前TIM I 3级与TMP 3级及PC I后TMP 3级比较差异均有统计学意义(P<0.05)。结论对急性STEM I急诊行PC I的患者,早期应用替罗非班能改善梗死相关血管的血流及心肌灌注。Objective To evaluate the effect of early Tirofiban using on the coronaryTIMI flow of IRA and myocardial reperfusion in patients with ST-segment elevation myocardial infarction（STEMI） undergoing primary percutaneous coronary intervention.Methods 160 patients with acute STEMI were enrolled and were divided into two groups,early group and immediately group.All patients were underwent primary percutaneous coronary intervention within 12 hours.The coronary TIMI flow grade and TMP grade of IRA before and after PCI,major adverse cardiac events（MACE） within 30days and bleeding complication were assessed.Results The incidences of TIMI 3 and TMP 3 in early group before PCI were 31.3% and 33.8%,the incidences of TIMI 3 and TMP 3 in early group after PCI were 92.5% and 75%;TIMI 3 before PCI and TMP 3 after PCI showed significant differences between the two groups（P〈0.05）.Conclusion Early Tirofiban administration can improve the coronary TIMI flow of IRA and myocardial perfusion in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

关 键 词：替罗非班 心肌梗死 冠状动脉介入 

分 类 号：R542.22[医药卫生—心血管疾病]