宫炎平分散片处方中辅料的筛选  

Optimization of the adjuvant materials of gongyanping dispersible tablets

作　　者：张毅[1] 张典瑞[1] 陈师农[2] 

机构地区：[1]山东大学药学院,山东济南250012 [2]安徽省药物研究所安徽省中药研究与开发重点实验室,安徽合肥230022

出　　处：《安徽医药》2010年第11期1251-1253,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的筛选宫炎平分散片处方中的辅料。方法采用正交试验法,以脆碎度、崩解时间、片面光洁度为指标,考察处方及制备工艺重现性。结果筛选出的最佳条件为干浸膏粉20 g、微晶纤维素60 g、乳糖10 g,PVPP 4 g、羧甲基淀粉钠8 g、30 ml的纯水作为黏合剂制备宫炎平分散片。结论此处方生产出来的产品各项指标均能符合规定,重现性好,能适合工业生产的要求。Aim To optimize the adjuvant materials of gongyanping dispersible tablets.Methods L9（34）orthogonal method was used to optimize the prescription.with friability,disintegration time,appearance of the tablets as the indexes,the reproducibility of prescription as also studied.Results The optimal prescription was dry herbs extract powder 20 g,microcrystalline cellulose 60 g,lactose 10 g,PVPP 4 g,and carboxymethyl starch sodium 8 g,with water 30 ml as binder.Conclusion This prescription meets the quality standard.The reproducibility is good,and suitable for batch manufatcture.

关 键 词：宫炎平分散片 崩解剂 稀释剂 黏合剂 

分 类 号：TQ461[化学工程—制药化工]