湖北咸宁地区正常人群与血吸虫疫区人群感染HBV基因型分析  

Genotyping Analysis of Hepatitis B Virus Among Normal Crowd and People from Schistosomiasis Epidemic Regions in Xianning,Hubei

作　　者：周建平[1] 王鸣[1] 王忠提[1] 张莉[1] 占建波[2] 杨红梅[3] 吕静[2] 詹发先[2] 

机构地区：[1]湖北省咸宁市疾病预防控制中心,湖北咸宁437100 [2]湖北省疾病预防控制中心 [3]十堰市疾病预防控制中心

出　　处：《实用预防医学》2010年第10期2096-2098,共3页Practical Preventive Medicine

摘　　要：目的了解咸宁市正常人群及血吸虫疫区人群乙肝病毒(HBV)基因型分布状态。方法取正常体检人员和血吸虫疫区例行体检人员中筛选出的HBsAg阳性携带者血清,用槽式PCR技术进行乙肝病毒基因分型检测。结果 86份HBsAg阳性血清标本(正常和血吸虫疫区人群分别43例)中检出B型69份(80.23%)、BC型10份(11.62%)、C型4份(4.65%)。结论咸宁地区正常人群感染HBV基因型均为B型,血吸虫疫区人群感染HBV基因型以B型为主,其次为C型、BC混合感染型。Objective To investigate the distribution of hepatitis B virus（HBV） genotypes among normal crowd and people from schistosomiasis epidemic regions in Xianning.Methods Eighty-six HBsAg positive serum samples were collected from the individuals who took part in a medical examination（n=43） and people from schistosomiasis epidemic regions（n=43）.Serum samples were separated and HBV genotypes were analyzed by Nested PCR.Results Among the 86 HBsAg positive serum samples,69（80.23%） were genotype B,10（11.62%） were genotype BC,and 4（4.65%） were genotype C.Conclusions HBV genotype B was found among normal people in Xianning; moreover,genotype B was predominant among people from schistosomiasis epidemic regions,followed by genotype C and genotype BC.

关 键 词：乙型肝炎病毒 基因型 检测 

分 类 号：R373.21[医药卫生—病原生物学]