非妊娠糖尿病巨大胎儿影响因素1:1病例对照研究  

Effect factors of fetal macrosomia without gestational diabetes:A 1:1 matching case-control study

作　　者：胡文斌[1] 沈月平[1] 刘银梅[1] 赵瑶[1] 罗晓明[2] 马小玲[2] 

机构地区：[1]苏州大学医学部放射医学与公共卫生学院流行病与卫生统计学教研室,江苏苏州215123 [2]江苏省昆山市妇幼保健所

出　　处：《中国妇幼保健》2010年第30期4405-4408,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金〔3082176〕;苏州大学医学发展基金重点项目〔EE126765〕

摘　　要：目的:探讨过去5年内昆山地区非妊娠糖尿病巨大胎儿发生的危险因素。方法:以2005～2009年在昆山市妇幼保健所登记的孕产妇及产后新生儿为研究对象,排除母亲孕前糖尿病和/或妊娠糖尿病因素,以巨大胎儿出生的孕周、民族为配对条件,采用1:1配比的病例对照研究,以此探究巨大胎儿发生的危险因素。结果:多因素调整后,条件Logistic回归分析结果显示,母亲年龄在32岁以上(OR=2.79,95%CI:1.45～5.39)、孕前体重在53kg以上、身高大于164cm(OR=2.08,95%CI:1.41～3.06),男孩(OR=1.51,95%CI:1.20～1.89)、父亲经常吸烟(OR=1.54,95%CI:1.13～2.10)等是巨大胎儿独立的危险因素;而父亲职业为干部或科技工作者(OR=0.61,95%CI:0.41～0.91)则是独立的保护性因素。结论:母亲生产年龄偏大、孕前体重偏高、身高偏高、男性胎儿、父亲经常吸烟等是巨大胎儿独立的危险因素;而父亲职业为干部或科技工作者则为巨大胎儿独立的保护性因素。Objective：To explore the risk factors of fetal macrosomia without gestational diabetes in the past 5 years in Kunshan area.Methods：The pregnant and lying-in women and their neonates who registered from 2005 to 2009 in Kunshan area were selected as research subjects,gestational weeks and nationalities were selected as matching conditions after excluding progestational diabetes and gestational diabetes,a 1：1 matching case-control study was adopted to explore the risk factors of fetal macrosomia without gestational diabetes.Results：Multivariate conditional logistic regression analysis indicated that mothers more than 32 years old（OR=2.79,95%CI：1.45～5.39）,progestational body weight53 kg,body height164 cm（OR=2.08,95%CI：1.41～3.06）,male fetus（OR=1.51,95%CI：1.2～1.89）,paternal smoking（OR=1.54,95%CI：1.13～2.10） were independent risk factors of fetal macrosomia;paternal occupation as official worker or researcher was a protective factor（OR=0.61,95%CI：0.41～0.91）.Conclusion：The independent risk factors of fetal macrosomia included maternal advanced age,high progestational body weight and body height,male fetus and paternal smoking;paternal occupation as official worker or researcher is a protective factor of fetal macrosomia.

关 键 词：巨大胎儿 非妊娠糖尿病 病例-对照研究 危险因素 

分 类 号：R714.51[医药卫生—妇产科学]