金柴抗病毒胶囊对甲型H1N1流感病毒FM1株感染免疫低下小鼠肺炎的影响  

Effect of Jinchai Antivirus Capsules on Prevention and Treatment of Influenza A H1N1 Virus in Immunodeficiency Mouse

作　　者：钟菊迎[1] 崔晓兰[2] 时宇静[2] 郭姗姗[1] 高英杰[2] 金亚宏[2] 曹洪欣[3] 

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700 [2]中国中医科学院中药研究所,北京100700 [3]中国中医科学院,北京100700

出　　处：《中国实验方剂学杂志》2010年第13期109-112,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制专项"课题(2009ZX09301-005-013)

摘　　要：目的:观察金柴抗病毒胶囊对H1N1流感病毒FM1感染免疫低下动物的防治作用。方法:采用环磷酰胺注射造成免疫低下模型,经滴鼻感染甲型H1N1流感病毒FM1株造成肺炎模型,分别经预防给药5 d和治疗4 d,取各组小鼠肺组织,称重,采用实时荧光定量聚合酶链式反应(RT-PCR)检测肺组织中相对病毒载量,观察金柴抗病毒胶囊对小鼠肺指数、病毒载量的影响。结果:模型组小鼠经流感病毒FM1株感染后,肺指数明显升高,肺组织中相对病毒载量显著高表达,金柴抗病毒胶囊各剂量组均可明显降低流感病毒感染免疫低下小鼠肺指数以及肺组织中相对病毒载量,降低动物模型肺指数、相对病毒载量的作用与达菲比较无显著性差异。结论:金柴抗病毒胶囊对流感病毒感染免疫低下小鼠有较好的治疗和预防作用。Objective： To investigate the effect of Jinchai Antivirus Capsules on immunodeficiency mouse with influenza A H1N1 virus（Fort Monmouth /1 /47） infection.Method： Mouse model of immunodeficiency was established by injection of cyclophosphamide.Infection of influenza virus FM1 was induced by nose dropping method.Prophylactic administration and therapeutic administration of the capsule were carried out respectively to observe the lung weight and calculate the lung index and virus load.Result： Jinchai Antivirus Capsules markedly decreased the lung index and virus load for the immunodeficiency mouse model with infuluenza virus.The antivirus efficacy was not statistically significant between the Capsules and Tamiflu.Conclusion： Jinchai Antivirus Capsules can distinctly improve the symptom of mouse with pneumonia caused by the infection of influenza virus and have a remarkable effect of prevention and therapy.The efficacy of Jinchai Antivirus Capsules is comparable to that of Tamiflu.

关 键 词：甲型H1N1流感病毒 金柴抗病毒胶囊 

分 类 号：R285.5[医药卫生—中药学]