地黄叶总苷对大鼠C-BSA肾炎的作用研究  

Effects of Total Saponins Extracted from Leaves of Rehmannia on C-BSA Nephritis in Rat

作　　者：沈欣[1] 李德凤[1] 宗桂珍[1] 吴子伦[1] 何伟[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2010年第13期167-169,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家高科技研究发展863计划项目(2004AA2Z3701)

摘　　要：目的:观察地黄叶总苷对大鼠阳离子化牛血清白蛋白(C-BSA)肾炎的治疗作用。方法:通过制备C-BSA(阳离子化牛血清白蛋白)对大鼠尾静脉进行注射造模后,给予本品口服4周观察对模型动物血生化、尿蛋白、肾脏病理等指标,评定受试物对该肾炎模型的治疗功效。结果:给药后,地黄叶总苷明显降低尿蛋白、血浆尿素氮、胆固醇和肌酐,病理形态学观察有明显改善(包括肾小球增大、系膜增生、小球内细胞增多等,亦可减少IgG和C3补体在肾小球的沉积。结论:地黄叶总苷20～40mg.kg-1口服4周,对大鼠C-BSA肾炎有明显的治疗作用,并且有一定的量效关系。Objective：To investigate therapeutic effects of total saponins extracted from leaves of rehmannia on C-BSA in rat.Method：Cationized bovine serum albumin（C-BSA） was prepared.For establishing nephritis in rat,C-BSA was given to rat by injection through tail venule.Total saponins extracted from leaves of rehmannia were orally given to the model rats as treatment for 28 days at doses of 20 ～ 40 mg.kg-1.Blood biochemeical parameters,urine protein and pathological changes of nephritis were employed to evaluate the efficacy of the treatment.Result： Compared with the model rats,urinary protein,serum urea nitrogen,cholesterol and creatinine were significantly increased.The pathological changes of nephritis were alleviated.Conclusion：Total saponins extracted from leaves of rehamannia has therapeutic effect with a dose-response manner on C-BSA nephritis in rat.

关 键 词：地黄叶总苷 阳离子化牛血清白蛋白(C—BSA).肾炎 抗体 

分 类 号：R285.5[医药卫生—中药学]