胃舒安胶囊对动物实验性胃溃疡的影响  

Effect of Weishu’an Capsule on Animal Experimental Gastric Ulcer

作　　者：沈鸿[1] 张英华[1] 田甲丽[1] 高英杰[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2010年第13期174-176,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究胃舒安胶囊对动物实验性胃溃疡的影响。方法:应用大鼠幽门结扎胃溃疡模型、大鼠醋酸胃溃疡模型、小鼠利血平所致胃溃疡模型,观察胃舒安胶囊对各型溃疡的影响。结果:胃舒安胶囊对幽门结扎性大鼠胃溃疡有明显防治作用;能显著抑制大鼠的胃液分泌,降低胃总酸度,抑制胃蛋白酶活性;对醋酸性大鼠胃溃疡有促进溃疡愈合的作用;对利血平所致小鼠胃溃疡有抑制作用。结论:胃舒安胶囊对动物实验性胃溃疡具有明显的防治作用。Objective：To research the effect of Weishu＇an Capsule on animal experimental gastric ulcer.Method：The effect of Weishu＇an Capsule on three kinds of modles of gastric ulcer was observed.The models included the model of pyloro-ligation gastric ucler in rats,the model of cautery gastric ulcer induced by acetic acid in rats and the model of reserpine-induced gastric ulcer in mice.Result： As to the pyloro-ligation gastric ucler,Weishu＇an Capsule could restrain the secretion of gastric juice,decrease the total gastric acidity,and restrain the activity of pepsin;as to the cautery gastric ulcer,it could promote the ulcer to be healed;as to the reserpine-induced gastric ulcer,it could restrain the ulcer.Conclusion： Weishu＇an Capsule has the obvious effect for preventing and treating the animal experimental gastric ulcer.

关 键 词：胃舒安胶囊 幽门结扎造模 醋酸造模 胃溃疡 

分 类 号：R285.5[医药卫生—中药学]