4,6-二羟基-5-氯嘧啶的合成  

Synthesis of 4,6-Dihydroxy-5-chloropyrimidine

作　　者：张国富[1] 项继聪[1] 范杰[1] 高晓茹[1] 何胜利[1] 丁成荣[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310032

出　　处：《农药》2010年第10期720-722,共3页Agrochemicals

基　　金：国家自然科学基金(20702051);浙江省教育厅科研计划项目(Y200907685);浙江工业大学应用化学省重中之重学科开放基金(56310101622)

摘　　要：以丙二酸二乙酯为原料,经NCS氯化得到2-氯丙二酸二乙酯,然后以甲醇为溶剂,在碱金属催化剂下,经与醋酸甲脒反应得到4,6-二羟基-5-氯嘧啶。反应总收率为73.4%(以丙二酸二乙酯计),含量为99.7%,其结构经红外和氢谱核磁分析确证。Diethyl chloromalonate was synthesized by chlorination of malonic ester with N-chlorosuccinimide.Then it reacted with formamidine acetate to give 4,6-dihydroxy-5-chloropyrimidine in the presence of alkali catalyst.The total yield was 73.4% based on malonic ester and the purity as high as 99.7%.The structure of the resulting product was confirmed by IR and 1H NMR.

关 键 词：丙二酸二乙酯 2-氯丙二酸二乙酯 4 6-二羟基-5-氯嘧啶 合成 

分 类 号：TQ254.1[化学工程—有机化工]