铁帚清浊丸对前列腺增生的影响及抗炎免疫作用  

Experimental Study on Effects of Tiezhou Qingzhuo Pill on Prostatic Hyperplasia,Anti-inflammation and Immunity Regulation

作　　者：周军[1] 韦桂宁[1] 李茂[1] 覃良[1] 李伟芳[1] 

机构地区：[1]广西中医药研究院,南宁530022

出　　处：《中国实验方剂学杂志》2010年第14期139-142,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:考察铁帚清浊丸对前列腺增生的影响及抗炎免疫作用。方法:给去势大鼠皮下注射丙酸睾酮诱导形成前列腺增生模型,观察铁帚清浊丸对抗前列腺增生的作用。大鼠足跖浮肿法、大鼠棉球植入法和小鼠耳肿胀法观察铁帚清浊丸的抗炎作用;小鼠碳粒廓清法和溶血素测定法观察铁帚清浊丸对免疫功能的调节作用。结果:铁帚清浊丸能显著抑制丙酸睾酮诱导去势大鼠前列腺的增生,降低前列腺指数的增加(P<0.05);显著抑制大鼠棉球肉芽肿增生、角叉菜胶致大鼠的足肿和二甲苯致小鼠的耳肿(P<0.05,P<0.01);显著提高小鼠HC50和碳末廓清指数(P<0.05)。结论:铁帚清浊丸具有抗炎,提高免疫力及抑制前列腺增生的作用。Objective：To observe the anti-inflammatory,immune regulating effect of Tiezhou Qingzhuo Pill（TZQZP） and its effects on prostatic hyperplasia.Method：The hyperplasia of prostate induced by testosterone in castrated rat was investigated.Anti-inflammatory was evaluated by paw edema test and cotton bailing granulation in rats,and ear tumefaction in mice;immune regulating effect was observed by the means of carbon particle clearance and haemolysin antibodies.Result：TZQZP could obviously inhibit the index of prostate in prostatitis rat（P 0.05）;inhibit the paw edema and cotton bailing granulation in rats,and ear tumefaction in mice（P 0.05,P 0.01）;enhance the phagocytic activity of monocytes and increased content of haemolysin antibody（P 0.05）.Conclusion：TZQZP has evident effects of anti-inflammation,immune regulation,and inhibition of prostatic hyperplasia.

关 键 词：铁帚清浊丸 前列腺增生 抗炎 免疫 

分 类 号：R285.5[医药卫生—中药学]