参莲方对高黏血症大鼠血液流变性的影响  

Influence of Danshen Chuanxinlian Decoction on Hemorheological Parameters in Rats with High Blood Viscosity

作　　者：陈丽娜[1] 李玉洁[1] 杨庆[1] 翁小刚[1] 周立运[1] 朱晓新[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2010年第14期154-156,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家直属科研院所技术开发研究专项资金[NCSTE-2007-JKZX-301];国家自然基金面上项目[30973901];中国中医科学院资助选题项目[ZZ2006117]

摘　　要：目的:观察参莲方对急性高黏血症模型大鼠血液流变性的影响。方法:50只大鼠随机分为参莲方高、中、低(2.7,1.35,0.68 g.kg-1)3个剂量组及空白对照组和模型组。连续给药7 d后,采用肾上腺素注射加冰浴的方法复制高黏血症模型,观察参莲方对血液流变学参数的影响。结果:与模型组比较,参莲方各剂量可降低全血黏度及血浆纤维蛋白原含量、降低血小板聚集率,延长凝血酶原时间。结论:参莲方可以明显改善高黏血症大鼠的血液流变性。Objective：To investigate the effects of Danshen Chuanxinlian Decoction（DCD） on the hemorheological parameters of the rat model with high blood viscosity.Method：Fifty rats were divided into 5 groups：control group,model group and experimental groups.After 7 days of medication,a model with high blood viscosity by injecting NE and iced bath,and observed the effects of these two herbs on hemocheological parameters.Result：Blood viscosity and the content of plasma fibrinogen were decreased in DCD group compared with those in model group,and the combination of Danshen and Chuanxinlian could inhibit platelet aggregation and prolong prothrombin time.Conclusion：The combination of Danshen and Chuanxinlian can obviously improve the hemorheological parameters in rats with high blood viscosity.

关 键 词：参莲方 高黏血症 血液流变学 

分 类 号：R285.5[医药卫生—中药学]