经皮冠状动脉介入对炎性因子白细胞介素-18影响的研究  

Studies on Interleukin-18 Before and After percutaneous coronary intervention therapy

作　　者：江华[1] 孙凯[1] 李智山[1] 刘文卫[1] 魏敏[1] 刘永胜[1] 

机构地区：[1]华中科技大学同济医学院附属襄樊医院检验科,湖北襄樊441021

出　　处：《国际检验医学杂志》2010年第10期1115-1116,共2页International Journal of Laboratory Medicine

摘　　要：目的观察经皮冠状动脉介入治疗(PCI)术前与术后血清白细胞介素-18(IL-18)的变化,并分析其临床意义。方法急性冠状动脉综合征(ACS)组84例并行PCI术;稳定型心绞痛(SAP)组31例,显示有冠状动脉不同程度狭窄,择期仅行冠状动脉造影而未行PCI术,另外冠脉造影正常55例患者作为正常对照组,采用酶联免疫吸附试验检测各组造影前及术后12h、术后2周血清IL-18浓度。结果 ACS组行PCI术后12hIL-18水平显著高于术前(P<0.01);而术后2周血清IL-18水平较术前明显降低(P<0.01)。正常对照组、SAP组和ACS组,其血清IL-18水平逐渐增高。结论 PCI术后存在炎性反应,IL-18是反映PCI后早期炎性反应的敏感指标,它的变化程度对不良心血管事件的发生可能具有预测价值。Objective To investigate the changes of serum interleukin-18 before and after percutaneous coronary intervention （PC1）therapy,for exploring the Clinical significance. Methods In 8/i patients with acute coronary syndrome（ACS）performed PCI, the levels of IL-18 were detected before and 12 hours, 2 weeks after therapy, compared with 31 cases of stable angina pectoris（SAP） and 55 control subjects. Results The levels of IL-18 were significantly higher 12 hours after PCI than that before PCI（P〈0.01）, but that 2 weeks after therapy were lower. Compared with control patients,IL-18 was significantly higher in patients performed PCI （P〈0.01）. Conclusion There is inflammation after PCI. IL-18 are sensilive to reflect early inflammation after PCI. There is correlation between the changes of IL-18 and cardiovascular events. The changing degree of IL-18 may be one of predictors for cardiovascular events after PCI.

关 键 词：血管成形术 经腔 经皮冠状动脉 白细胞介素18 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]