对羟基苯乙酮的合成研究  

Research on synthesis of p-hydroxyacetophenone

作　　者：张正[1] 杨盟辉[1] 段远富[1] 

机构地区：[1]中国人民解放军61788部队

出　　处：《化学工程师》2010年第10期55-56,共2页Chemical Engineer

摘　　要：以苯甲醚、乙酰氯为原料,AlCl3为催化剂通过Friedel-Crafts酰基化反应和脱甲基化两步反应得到对羟基苯乙酮。考查了反应时间、反应温度等条件对反应的影响,确定了反应的最佳条件。在最佳工艺条件下对羟基苯乙酮的总收率为65%,经熔点和红外光谱表征与目标化合物的结构一致。The p-hydroxyacetophenoen was synthesized from anisole,acetyl chloride as starting materials and AlCl3 as catalyst through Friedel-Crafts acylation and demethylation.The influence factors of reaction time and reaction temperature were studied,and the optimal reaction conditions were obtained.The total yield of p-hydroxyacetophenoen was 65%.The result was confirmed by melting point and infrared spectrum.

关 键 词：对羟基苯乙酮 Friedel-Crafts酰基化 脱甲基化 合成 

分 类 号：O621.3[理学—有机化学]