鲍曼不动杆菌医院感染分布及耐药性分析  

Distribution and drug resistance of Acinetobacter baumannii in nosocomial infections

作　　者：索明环[1] 孙各琴[1] 莫姗[1] 王柏旺[1] 曾宗跃[1] 陈冬梅[1] 胡婷[1] 徐全中[1] 

机构地区：[1]广东省中山市人民医院检验医学中心,广东中山528400

出　　处：《中国病原生物学杂志》2010年第10期777-778,781,共3页Journal of Pathogen Biology

摘　　要：目的探讨医院感染鲍曼不动杆菌（ABA）在临床标本中的分布及耐药性,为临床医师合理用药提供科学依据。方法采用微量稀释法对临床送检标本分离的ABA菌株进行药敏试验,分析其耐药性。结果从临床标本中分离出347株ABA菌株,主要来源于痰液（占67.4%）,科室主要分布于重症监护病房（ICU）、呼吸内科、中医康复科和神经内科等。ABA对亚胺培南的敏感率为78.4%,对头孢他啶、妥布霉素、左旋氧氟沙星、头孢吡肟、环丙沙星、复方新诺明和庆大霉素的敏感率在30%~41%之间,对氨苄西林的敏感率仅为6.1%。ABA对以上抗菌药物的敏感率呈逐年下降趋势。结论鲍曼不动杆菌耐药性已十分严重,临床应根据药敏结果合理使用抗生素。Objective To investigate the distribution and drug resistance of Acinetobacter baumannii in nosocomial infections to provide scientific evidence for the clinical use of antibiotics.Methods Drug sensitivity testing of A.baumannii isolated from clinical specimens was performed with a broth microdilution test and its drug resistance was analyzed.Results A total of 347 strains of A.baumannii were mainly isolated from sputum（about 67.4%） and mainly isolated from the intensive care unit（ICU） and departments of respiratory medicine,rehabilitation,and neurology.Testing A.baumannii sensitivity to 9 kinds of antibiotics indicated its sensitivity to imipenem（78.4%）.A.baumannii sensitivity to ceftazidime,tobramycin,levofloxacin,cefepime,ciprofloxacin,trimethoprim/sulfamethoxazole,and gentamicin was about 30%-41%.Its sensitivity to ampicillin was only 6%.The sensitivity of A.baumannii to 9 kinds of antibiotics has tended to decrease.Conclusion Drug resistance of A.baumannii is a very serious issue.Clinicians should use antibiotics rationally according to the results of drug susceptibility tests.

关 键 词：医院感染 鲍曼不动杆菌 分布 耐药性 

分 类 号：R378.99[医药卫生—病原生物学]