水溶性呋喃西林固体分散体配方及工艺研究  

Study on the Preparation for Water-Soluble Solid Dispersion of Furacilin

作　　者：庄志铨[1] 陈吉生[1] 吕剑豪[1] 

机构地区：[1]广东药学院附属第一医院,广东广州510080

出　　处：《今日药学》2010年第10期7-9,共3页Pharmacy Today

基　　金：广东省医院药学研究基金(编号:2009A010)

摘　　要：目的利用固体分散技术制备水溶性呋喃西林固体分散体,增加其溶解度。方法选择聚乙二醇6000(PEG)为载体,采用熔融法、溶剂-熔融法,按药物与载体1:3、1:6、1:9的比例分别制成不同的呋喃西林固体分散体,将呋喃西林原药与呋喃西林固体分散体进行体外溶出度试验和溶解度试验。结果呋喃西林固体分散体的体外溶出度和溶解度与呋喃西林原药相比显著增大。结论选择呋喃西林与聚乙二醇(PEG)-6000(1:6)及溶剂-熔融法作为水溶性呋喃西林固体分散体的配方及工艺,可使呋喃西林的溶解度提高。Objective To increase the solubility of furacilin by preparing its solid dispersion.Methods Different solid dispersion of furacillin were prepared by using the melting method and solvent-melting method,with polyethylene glycol 6000 （PEG） as a carrier.The ratio of drug and carrier was 1：3,1：6,and 1：9 repectively.In vitro dissolution and solubility tests were compared between the original drug and furacilin solid dispersions.Results The in vitro dissolution and solubility of furacilin solid dispersion was significantly increased comparing with the original drug.Conclusion The dissolution of furacilin can be improved by mixing furacilin and polyethylene glycol （PEG）-6000 in a ratio of 1：6 in solvent–melting method.

关 键 词：呋喃西林 固体分散体 聚乙二醇 溶出度 

分 类 号：R91[医药卫生—药学]