化疗药物性静脉炎及渗漏损伤的动物实验模型研究概况  

Review of Animal Experimental Model of Phlebitis Induced by Chemotherapy and Damage Caused by Extravasation of Chemotherapeutic Agents

作　　者：张丞[1] 纪荣[1] 国旭祺[1] 杨延龙[2] 苏永华[2] 

机构地区：[1]第二军医大学,上海200433 [2]上海长海医院,上海200433

出　　处：《辽宁中医药大学学报》2010年第11期44-46,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然基金资助项目(30672569);上海市科技委员会科技启明星计划资助项目(05QMX1471)

摘　　要：化疗药物性静脉炎及渗漏损伤的动物实验模型是研究体内化疗药物性静脉炎及渗漏损伤的发病机制和评价各种治疗方法的重要条件。化疗药物性静脉炎及渗漏损伤的实验研究进展缓慢,其主要原因是缺乏理想的动物模型。依文献报道,化疗药物性静脉炎模型主要以大白兔耳缘静脉注射长春瑞滨等化疗药物为多见,化疗药物渗漏损伤模型主要以大鼠及大白兔背部皮下注射盐酸阿霉素等化疗药物为多见。文章就近年来常用的一些化疗药物性静脉炎及渗漏损伤的动物模型综述如下。The animal experimental model of phlebitis induced by chemotherapy and damage caused by the extravasation of chemotherapeutic agents is the important factor to research their pathogenesis and to evaluate effects of several therapies.Experimental study on phlebitis induced by chemotherapy and damage caused by extravasation develops slowly mainly because of lacking a satisfying animal experimental model.According to the paper,the common animal experimental models of phlebitis induced by chemotherapy are made by injecting rabbits into their ear veins with Vinorelbine,while those of damage caused by the extravasation of chemotherapeutic agents are made by hypodermically injecting in the back of rats or rabbits with Adriamycin.Here is the review of animal experimental model of phlebitis induced by chemotherapy and damage caused by extravasation in recently few years.

关 键 词：化疗性静脉炎 渗漏损伤 动物实验模型 

分 类 号：R543.6[医药卫生—心血管疾病]