眼眶静脉畸形的临床病理研究  

A clinical pathological study on orbital venous malformations

作　　者：林明[1] 李瑾[1] 贾仁兵[1] 黄晓玲[1] 范先群[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院眼科,上海200011

出　　处：《实用医院临床杂志》2010年第6期23-26,共4页Practical Journal of Clinical Medicine

基　　金：上海市重点学科(编号:S30205);上海市科委重点课题资助项目(编号:04JC14041)

摘　　要：目的分析眼眶静脉畸形(Orbital vascular malformation,OVM)的分型与病理联系,研究不同OVM分型中基质金属蛋白酶MMP-9、血小板粘附因子(CD31)、血管内皮生长因子(VEGF)和α平滑肌肌动蛋白(α-SMA)的表达情况,探讨OVM的发病机制。方法收集2005年1月至2009年12月手术切除的32例OVM病例,根据临床表现及影像学检查分为扩张型OVM和非扩张型OVM2型,收集病理标本,行HE染色和免疫组织化学染色,观察并分析:①OVM的分型与病理联系;②MMP-9、CD31、VEGF和α-SMA在各型OVM的表达情况。结果本组病例扩张型21例(65.63%),非扩张型11例(34.37%);免疫组化染色显示扩张型OVM的CD31和α-SMA表达低于非扩张型,而MMP-9表达高于非扩张型,二型VEGF表达差异无统计学意义。结论不同类型的OVM具有特征性的病理特点;MMP-9、CD31和α-SMA在扩张型和非扩张型OVM中的表达有明显差异,可能作为OVM临床诊断的辅助指标。Objective To observe the histopathological changes of orbital venous malformations （OVM）,study the relationship between its types and the expression of MMP-9,CD31,VEGF and α-SMA,and preliminary analyze its pathogenesis.Methods Thirty-two patients with OVM were treated during January 2005 to Decmenber 2009.According to the clinical observations and CT scan examinations,we divided OVM into two types,distensible and nondistensible.The histopathological changes were observed,and the expression of MMP-9,CD31,VEGF and α-SMA was determinated by immunohistochemical technique.Results Thirty-two patients were divided into two types,21 distensible OVM and 11 nondistensible OVM.The expression of CD31and α-SMA in distensible type was lower than that in nondistensible type,and the expression of MMP-9 in distensible type was higher than that in nondistensible type.Conclusion The histopathological changes of each type of OVM are different,the expression of MMP-9 in OVM is markedly higher,both of which could act as assistants in the diagnosis and treatment of OVM.

关 键 词：MMP-9 眼眶静脉畸形 免疫组织化学染色 病理 

分 类 号：R654.4[医药卫生—外科学] R365[医药卫生—临床医学]