血清Cys C测定对于判断早期肾功能损害的应用评价  

Apprasial of the Clinical Usefulness of Determination of Serum Cys C Levels for Early Detection of Renal Function Impairment

作　　者：贾宁人[1] 卢鸿浩[2,3] 吴家明[4] 芮志莲 王宁皎[1] 蒋维[1] 陶兴[5] 仲昱[5] 孙伟[5] 

机构地区：[1]江苏省中医院检验科,210029 [2]东南大学 [3]南京市江宁中医院 [4]溧阳市人民医院 [5]溧阳市人民医院肾内科

出　　处：《放射免疫学杂志》2010年第5期567-569,共3页Journal of Radioimmanology

基　　金：2004年常州市卫生局科技项目

摘　　要：目的:探讨血清胱抑素蛋白酶抑制剂C(CysC)在早期肾功能损害判断中的相关性评价。方法:运用已建立的颗粒增强免疫透射比浊法测定血清CysC,测定了116例慢性肾脏病患者血中的CysC浓度,同时分别测定了患者血中的Cr、UAER、β2-m常规检测项目,以48例健康人作为对照。结果:慢性肾脏病患者与正常对照组比较及肾功能损害不同时期比较CysC差异有显著意义,各检测指标与Ccr呈相关性,且CysC与Ccr的相关性优于其它指标。结论:血清CysC浓度在慢性肾脏病患者肾功能不同损害期均能准确反映Ccr,即能准确反映肾小球滤过功能,尤其能敏感提示早期肾功能损害,可成为判断肾功能损害程度的敏感指标。Objective To evaluate the validity of serum Cystatin C （Cys C） as an indicator in diagnosis of early stage of renal failure.Methods Serum Cys C levels were determined with an automated particle-enhanced turbidimetric immunoassay method established by us in 116 patients with chronic kidney disease and 48 controls.Serum creatinine,urea and beta-microglobulin levels were also determined.Results Serum Cys C levels were elevated in patients with quite early renal injury （Ccr still over 90ml/ min） （vs controls P 〈0.05） .Serum Cys C was more strongly positively correlated with Ccr （r =-0.8082） than creatinine,urea and beta-microglobulin were.Conclusion Serum Cystatin C may be used as a marker of early renal injury in patients with chronic kidney disease.

关 键 词：胱抑素蛋白酶抑制剂C 内生肌酐清除率 肾小球滤过功能 慢性肾脏病 

分 类 号：R544.1[医药卫生—心血管疾病]