动态监测hs-CRP在新生儿感染中的临床意义  

Clinical Significance of Serial Determination of Serum High Sensitivity C-reactive Protein (hs-CRP) Levels in Neonatal Infection

作　　者：佘尚扬[1] 李小妹[1] 韦秋芬[2] 岳海英[1] 曾尚娟[1] 闫芳[1] 胡雪桦[1] 周春浪[1] 唐玉群[1] 

机构地区：[1]广西壮族自治区妇幼保健院检验科,530003 [2]广西壮族自治区妇幼保健院新生儿科,530003

出　　处：《放射免疫学杂志》2010年第5期577-579,共3页Journal of Radioimmanology

基　　金：广西壮族自治区卫生厅自筹经费课题(Z2008201)

摘　　要：目的:探讨动态监测超敏CRP(hs-CRP)在新生儿感染性疾病中的临床意义。方法:采用免疫荧光双抗体夹心法,检测112例出生1周内新生儿感染性疾病患儿治疗前后血清CRP的动态变化,其中90例为缓解组患儿,22例为加重组患儿,并以100例健康新生儿作为对照组。结果:缓解组患儿治疗前hs-CRP水平显著地高于正常儿组(P<0.05),治疗后逐渐下降,治疗(3～5)d后降到正常儿水平(P>0.05);加重组患儿治疗前hs-CRP低于正常儿组,治疗(3～5)d后,因病情加重,hs-CRP显著升高(P<0.05),治疗(7～10)d后炎症受控制,hs-CRP逐渐降低。结论:hs-CRP随着病情的缓解而下降,随着疾病的加重而上升。动态hs-CRP可作为临床对新生儿感染性疾病监测、疗效观察等良好的实验室指标。Objective To evaluate the clinical significance of serial determination of serum high sensitivity C-reactive protein （hs-CRP） levels in neonatal infection.Methods Serum hs-CRP levels were detected dynamically with double antibody immunoassay in 112 neonates with infectious diseases before and during treatment as well as once in 100 controls.These patients were of two groups： ① Group A： 90 patients were gradually improving from the beginning and ② Group B： 22 patients were deteriorating at first and then gradually improved after freatment.Results In group A,the hs-CRP levels before treatment were significantly higher than those in the controls.The levels were decreased after treatment and became normal in 3 ～ 5 days.In group B,the hs-CRP levels before treatment were lower than those in the controls,but the levels were raised up in 3 ～ 5 days with the aggravation of inflammation and then turned downh in 7 ～ 10 days after improvement.Conclusion Serum hs-CRP levels decreased with alleviation of inflammation and increased with aggravation of inflammation.Serial hs-CRP levels determinations were useful in monitoring disease activity and response to therapy.

关 键 词：新生儿 C-反应蛋白 感染性疾病 

分 类 号：R722.13[医药卫生—儿科]