支气管哮喘与咳嗽变异性哮喘最大气道反应性的特点分析  

The Comparison of Airway Response Between Bronchial Asthma and Cough-Variant Asthma

作　　者：张学文[1] 赵宇[1] 陈济明 

机构地区：[1]深圳市第八人民医院,广东深圳518101 [2]深圳市南山人民医院,广东深圳518100

出　　处：《中外医疗》2010年第27期19-20,共2页China & Foreign Medical Treatment

摘　　要：目的研究对比支气管哮喘与咳嗽变异性哮喘之间最大气道反应性之间的差异性及其反应平台的分布情况。方法支气管哮喘组患者46例和咳嗽变异性哮喘组患者42例分别吸入较高浓度的乙酰甲胆碱作为支气管激发剂,当FEV1下降至激发前水平的50%或出现最大反应平台后终止实验,最终分析比较2组出现反应平台所占的比例及平台水平值。结果支气管哮喘组有16例患者出现反应平台所占的比例为34.8%,显著低于咳嗽变异性哮喘组24(57.1%),反应平台的水平值支气管哮喘组显著高于咳嗽变异性哮喘组(P<0.05),但2组PC20无显著性差异。结论最大气道反应性可表明哮喘气道高的灵敏度与其临床表现和病情的严重程度有较大的相关性,且支气管哮喘的气道反应性显著高于咳嗽变异性哮喘。Objective To investigate the difference of maximal airway response and compare the prevalence of response plateau between patients with bronchial asthma （BA） and those with cough-variant asthma（CVA）.Methods There were 46 patients in BA group and 42 patients in CVA group.High-dose methacholine inhalation test were carried out in patients in BA group and CVA group respectively.The procedure was terminated when the FEV1 fell below 50% of pre-provocation test,or while maximal response plateau were established.Ultimatly,we compared the proportion of response plateau and the level of it between the tow groups. Results 16（34.8%）patients in BA group and 24（57.1%）in CVA group showed maximal response plateau and there were significant difference between the tow groups.Patients in BA and CVA group showing a response plateau had significantly different plateau level（P0.05）,however,the PC20 between the tow groups hadn’t statistical significance.Conclusion Maximal airway response may demonstrate the correlation between the airway hypersensitivity and clinical expression,severity of the disease. Furthermore, bronchial asthma have higher airway response than cough-variant asthma.

关 键 词：支气管哮喘 咳嗽变异性哮喘 气道反应性 

分 类 号：R562.25[医药卫生—呼吸系统]