冠状动脉粥样硬化的CTA成像及其常见危险因素的临床分析  

Computed Tomographic Angiography and Clinical Analysis of the Common Factors for Coronary Atherosclerosis

作　　者：田作军[1] 邓宇[2] 王涛[3] 曾昭华[3] 周玉兰[3] 由天辉[4] 陆亚琴[5] 

机构地区：[1]广州医学院第一附属医院神经内科,广州510120 [2]广州医学院第一附属医院放射科,广州510120 [3]广州医学院第一附属医院心内科,广州510120 [4]广东药学院护理学院,广州510310 [5]广州医学院护理学院,广州510180

出　　处：《热带医学杂志》2010年第9期1087-1090,共4页Journal of Tropical Medicine

基　　金：广东省科技计划项目(No.2009B030801341);广州市属高校科技计划项目(No.08A094)

摘　　要：目的探讨冠状动脉粥样硬化的CTA成像技术及其临床常见危险因素。方法首先对2005年6月-2009年1月入住本院的276例疑诊冠心病患者用16层螺旋CT进行冠脉CTA检查,然后根据CTA结果将资料分为冠心病组和非冠心病组,以卡方检验及二项分类Logistic回归分析影响冠状动脉狭窄程度的常见危险因素。结果 CTA成像一次检查可完成冠状动脉钙化积分和狭窄的评价,图像清晰,方便、安全。卡方检验结果显示:冠状动脉狭窄程度受年龄(χ2=13.560,P=0.001)、抽烟(χ2=4.243,P=0.039)、TC(χ2=8.260,P=0.004)、TG(χ2=5.718,P=0.017)、LDL(χ2=6.375,P=0.012)影响;Logistic回归分析发现:吸烟(OR=3.136,P=0.003)、TC(OR=2.370,P=0.004)、高血压(OR=2.247,P=0.015)、年龄(OR=1.064,P=0.000)与冠状动脉的狭窄程度相关性更密切。结论本研究发现冠脉CTA成像可作为常规的冠心病筛选影像技术;吸烟、总胆固醇、高血压和年龄与冠状动脉的狭窄程度临床相关性更密切,LDL、TG相关性相对较小。Objective To explore the technique of computed tomographic angiography （CTA） and the common clinical factors for coronary atherosclerosis.Methods From Jun 2005 to January 2009, 276 hospital patients with doubtful coronary heart disease underwent the examination of sixteen-slice spiral CT coronary angiography.The patients were divided into two groups：with and without coronary artery disease according to the result of cardiac CTA.Chi square test and binary logistic regression were used to analyze the common risk factors for coronary atherosclerosis.Results In one study of CTA, coronary calcium score and coronary artery stenosis can be both evaluated.The imaging of cardiac CTA was distinct and the procedure was simple and safe.Chi square test showed that the formation of coronary atherosclerosis was subjected to influences by age （χ2=13.560, P=0.001）, smoking （χ2=4.243, P=0.039）, total cholesterol （χ2=8.260, P=0.004）, triglyceride （χ2=5.718, P=0.017） and low density lipoprotein （χ2=6.375, P= 0.012）.The binary logistic regression analysis indicated that smoking （OR=3.136, P=0.003）, total cholesterol （OR= 2.370, P=0.004）, hypertension （OR=2.247, P=0.015） and age （OR=1.064, P=0.000） are closely correlated to the degree of coronary atherosclerosis.Conclusion Cardiac CTA can be used as a routine imaging screening tool for high-risk groups of coronary heart disease.Smoking, total cholesterol, hypertension and age show clinically closer correlation to the degree of coronary atherosclerosis than low density lipoprotein and triglyceride.

关 键 词：冠状动脉粥样硬化 CTA 年龄 吸烟 高血压 血脂 

分 类 号：R543.5[医药卫生—心血管疾病]