Toll样受体8及其免疫学功能研究进展  

Progresses in Toll-like receptor 8 and its immune function

作　　者：李立辉[1] 郑世民[1] 

机构地区：[1]东北农业大学动物医学学院病理生理学教研室,哈尔滨150030

出　　处：《免疫学杂志》2010年第10期913-915,共3页Immunological Journal

基　　金：黑龙江省自然基金项目(C200841)

摘　　要：Toll样受体8(toll-like receptor8,TLR8)不但能识别某些人工合成的具有抗病毒和抗肿瘤作用的小分子化合物,还可识别单链RNA病毒、鸟嘌呤核苷酸衍生物、特定合成的单链寡核苷酸(oligoribonucleotide,ORN)及双链小干扰RNA序列。活化TLR8启动髓系分化因子88(myoloid differentiation factor 88,MyD88)依赖的信号通路,介导相应免疫应答。对TLR8及其免疫学功能深入系统的研究将对机体抗病毒感染和肿瘤治疗开辟新途径。本文对TLR8及其免疫学功能近年研究进展做了简要总结。Toll-like receptor 8（TLR8） not only can recognize some small antiviral and antitumor molecular compounds,but also can recognize single-stranded RNA virus,guanosine analogs,certain synthetic single-stranded oligoribonucleotides（ORN） and double-stranded small interfering RNA sequence.The activated TLR8 triggers myeloid differentiation factor 88-depended signal pathway to induce immune response.The penetrating and systemic research of TLR8 and its immune function will open a new way for virus infection defending and tumor treatment.This article summarizes the approaches in TLR8 and its immune function research.

关 键 词：Toll样受体8 分子结构 特异配体 信号转导 免疫学功能 

分 类 号：R392.3[医药卫生—免疫学]