与2型糖尿病相关糖复合物中糖链结构变化  

Type 2 Diabetes Mellitus-associated Structural Alteration of Glycans in Glycoconjugates

作　　者：王培培[1] 于广利[1] 郝杰杰[1] 

机构地区：[1]中国海洋大学医药学院,海洋药物教育部重点实验室及山东省糖科学与糖工程重点实验室,青岛266003

出　　处：《中国生物化学与分子生物学报》2010年第10期898-902,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家高技术研究发展计划项目(863计划;No.2007AA09Z445);国际科技合作项目(No.2007DFA30980);国家自然科学基金(No.30870506和No.31070724)项目资助~~

摘　　要：2型糖尿病是一种全球性严重危害人类健康的慢性代谢性疾病.在2型糖尿病患者和动物的血液、尿液及受损组织中,糖链的结构均发生了不同程度的变化.本文对近年来有关2型糖尿病发生、发展过程中糖蛋白、蛋白聚糖和糖脂中糖链的结构变化进行综述,为2型糖尿病的诊断及其相关药物的研发提供有用的参考.Type 2 diabetes mellitus （T2DM） is a worldwide chronic metabolic disease that is seriously harmful to human＇s health.The contents and structures of glycans in the blood,urine and injury tissues of T2DM animal and human body are all changed in different levels.In this paper,the structural changes of glycans in glycoprotein,proteoglycan and glycolipid related to the development process of T2DM were reviewed,and this review would be helpful for the diagnosis of T2DM,and also offered useful references for T2DM-related medicaments during the related research and development.

关 键 词：2型糖尿病 糖蛋白 蛋白聚糖 糖脂 

分 类 号：Q53[生物学—生物化学]