基质金属蛋白酶在双肾一夹型高血压大鼠血管重塑中的表达及替米沙坦的作用  

Expression of MMP and the reversal effect of telmisartan on vascular remodeling in 2K1C hypertension rats

作　　者：闫宏[1] 孙刚[1] 金刚[1] 

机构地区：[1]内蒙古包头医学院第二附属医院心内科,014030

出　　处：《临床心血管病杂志》2010年第10期784-786,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨基质金属蛋白酶-2、9(MMP-2、9)在双肾一夹型高血压大鼠血管重塑中的表达及其调节机制。方法:将雄性Wistar大鼠随机分成3组,假手术(对照)组,双肾一夹型(模型)组,替米沙坦组,均在术后每周监测血压,8周后处死大鼠取胸主动脉与颈总动脉作形态学观察,免疫组化法检测MMP-2、9的蛋白表达。结果:与对照组相比,模型组血压明显升高,血管中膜增厚,MMP-2、9表达显著增加。治疗8周后,替米沙坦组血压明显降低,管壁变薄,MMP-2、9表达减少。结论:MMP-2、9可能与高血压血管重塑有关,替米沙坦通过抑制血管中MMP-2,9的表达,改善血管重塑。Objective：To explore the expression and mechanisms of MMP-2,9 on vascular remodeling of twokidney one-cliped（2KIC）hypertensive rat.Method：Male Wistar rats were randomly divided into sham operation group（n=10）,2KIC model group（n=10）and telmisartan group（n=7）.The blood pressure was determined every week.The morphologic changes of carotid artery and thoracic aorta were observed with HE staining after 8 weeks.Arteries was performed to valuate the expression of MMP-2,9 with mmunohistochemisty.Result：The blood pressure,vessel wall,and the expression of MMP-2,9 in model group were significantly increased compased with those of control group.After treatment with telmisartan,all of them were decreased.Conclusion： MMP-2 and 9 are related to vascular remodeling in 2KIC hypertensive rat and telmisartan could regulate vascular remodeling by inhibiting the expression of MMP-2and 9.

关 键 词：高血压 基质金属蛋白酶 双肾一夹型高血压 血管重塑 替米沙坦 

分 类 号：R544.1[医药卫生—心血管疾病]