红花黄色素注射液对急性非ST段抬高型心肌梗死患者血小板聚集率和转化生长因子β_1的影响  

Effect of administration of Safflower yellow injection on the platelet aggregate rate and transforming growth factor-β_1 in patients without ST elevation acute myocardial infarciton

作　　者：郭张强[1] 成忠[1] 李论[1] 刘启云[1] 吴洪波[1] 顾晔[1] 

机构地区：[1]华中科技大学同济医学院附属普爱医院心内科,武汉430033

出　　处：《临床心血管病杂志》2010年第8期591-593,共3页Journal of Clinical Cardiology

摘　　要：目的:研究红花黄色素注射液对急性非ST段抬高型心肌梗死(NSTEMI)患者血小板聚集率和转化生长因子β1(TGF-β1)的影响,探讨红花黄色素注射液在NSTEMI的作用机制。方法:将65例NSTEMI患者随机分为红花黄色素注射液治疗组(治疗组)和常规治疗组(对照组)。治疗组在常规治疗的基础上静脉点滴红花黄色素注射液,100ml/次,1次/d。检测2组治疗前后血小板聚集率、TGF-β1、高敏C反应蛋白。结果:治疗组血小板聚集率、TGF-β1、高敏C反应蛋白均较对照组显著降低(P<0.05)。结论:红花黄色素注射液可改善NSTE-MI患者的预后,可以作为治疗心肌梗死的辅助药物。Objective：To study the effects of Safflower yellow injection on the platelet aggregate rate and transforming growth factor-β1 （TGF-β1） in patients without ST elevation acute myocardial infarciton （NSTEAMI） and therefore,provide new theory for the immunoregulation mechanism of Safflower yellow injection in the AMI.Method：We prospectively studied 65 patients underwent NSTEAMI,who were random designated to Safflower yellow injection group treated with Safflower yellow injection （35 cases） and routine group without Safflower yellow injection treated （30 cases） for 10 days.Platelet aggregate rate,hs-CRP and TGF-β1 in the peripheral blood were measured at admission and 10 days.Result：The level of platelet aggregate rate,TGF-β1 and hs-CRP in the AMI group were significantly lower than those in control group （P0.05）.Conclusion：Safflower yellow injection can improve the prognosis of the NSTEAMI patients,suggesting a possible mechanism of Safflower yellow in the immunoregulation role in the AMI.Safflower yellow may be an adjuvant therapy in the AMI.

关 键 词：心肌梗死 红花黄色素注射液 血小板聚集率 转化生长因子Β1 

分 类 号：R542.2[医药卫生—心血管疾病]