含羟基的3—苯基—4—（1H）—喹啉酮衍生物的^1H NMR  

~1H NMR OF 3 PHENYL 4(1H) QUINOLINONE DERIVATIVES

作　　者：徐鸣夏[1] 王晓莉[1] 郑虎[1] 

机构地区：[1]华西医科大学药学院,成都61004

出　　处：《波谱学杂志》1999年第2期169-172,共4页Chinese Journal of Magnetic Resonance

摘　　要：在抗骨质疏松药物的设计中，根据电子等排原理和药物的构效关系理论，设计并同时合成了７羟基３苯基４（１Ｈ）喹啉酮新衍生物以及其同分异构体５羟基３苯基４（１Ｈ）喹啉酮新衍生物．本文报道上述新化合物的１Ｈ ＮＭＲIsoflavonoids possess estrogenicity and antiosteoporosis. 3 phenyl 4(1H) quinolinone derivatives are isosteres of isoflavonoids. We proposed that 7 hydroxy 3 phenyl 4(1H) quinolinone derivaties can also exhibit similar activities 5 hydroxy 3 phenyl 4(1H) quinolinone derivatives are isomers of 7 hydroxy 3 phenyl 4(1H) quinolinone derivatives. They were designed and synthesized for antiosteoporosis. None of them been reported in literature. The \{\}\+1H NMR data are listed in detail in this article. \;

关 键 词：苯基 喹啉酮衍生物 氢1 NMR 抗骨质疏松药 

分 类 号：R982[医药卫生—药品]