羟丁酸钠对布比卡因致惊厥作用的影响  

Influences of Sodium Oxybate on Convulsant Effect of Bupivacaine

作　　者：赵娟[1] 赵志龙[1] 申璐[2] 王贺[2] 周美艳[3] 戴体俊[4] 

机构地区：[1]徐州医学院麻醉学院,徐州221002 [2]徐州医学院公共卫生学院,徐州221002 [3]徐州医学院药理学研究生部,徐州221002 [4]徐州医学院麻醉药理学教研室,徐州221002

出　　处：《药学与临床研究》2010年第5期435-437,共3页Pharmaceutical and Clinical Research

基　　金：国家自然科学基金资助项目(39970715);江苏省自然科学基金资助项目(BK200143)

摘　　要：目的:观察羟丁酸钠对布比卡因致惊厥作用及半数有效量(ED50)、半数致死量(LD50)的影响。方法:皮下注射3种不同剂量羟丁酸钠30 min后,腹腔注射致惊厥作用的布比卡因,观察小鼠惊厥的潜伏期、持续期、未惊厥数、死亡情况和惊厥分级;并以序贯法测定预先给羟丁酸钠30min后布比卡因的致惊厥ED50和LD50。结果:50mg.kg-1的羟丁酸钠可缩短布比卡因致惊厥的持续期(P<0.05),100、200mg.kg-1的羟丁酸钠可延长布比卡因致惊厥的潜伏期(P<0.01)、缩短持续期(P<0.01)、减少惊厥发生率和死亡率,降低惊厥发作等级;增大布比卡因致惊厥的ED50(P<0.05,P<0.01),增大布比卡因的LD50(P<0.01)。结论:羟丁酸钠可拮抗布比卡因的致惊厥作用,降低布比卡因的毒性。Objective： To observe the influences of sodium oxybate on convulsant action and LD50 effects of bupivacaine. Methods： Three doses of sodium oxybate were administered hypodermically, and thirty minutes later, bupivacaine was administered intraperitoneally. The convulsant latency period, convulsion duration, incidence of no convulsion, mortality and grade of convulsion were observed and recorded, and the LD50 and ED50 were analyzed by sequential method in mice. Result： The latency of bupivacaine induced convulsion was extended by sodium oxybate, the convulsion duration was shorten, the incidence of convulsion and mortality were reduced, and the grade of convulsion was cut down. The EDs0 and LDso of bupivacaine-induced convulsion were improved by sodium oxybate（100 mg·kg^-1, 200mg·kg^-1） （P〈0.01）. Conclusions： Sodium oxybate can antagonize the bupivacaine induced convulsion, reduce the toxicity of bupivacaine.

关 键 词：羟丁酸钠 布比卡因 惊厥 ED50 LD50 

分 类 号：R969.2[医药卫生—药理学] R971.2[医药卫生—药学]