异丙嗪对小鼠利多卡因致惊厥作用的影响  

Effect of Promethazine on Convulsion Function Caused by Lidocaine in Mice

作　　者：纪月珑[1] 孟尹[1] 朱颖君[1] 刘亚君[2] 何珂[3] 戴体俊[4] 

机构地区：[1]徐州医学院麻醉学院,2006级灌注班徐州221004 [2]徐州医学院研究生部,徐州221004 [3]徐州医学院临床医学一系,徐州221004 [4]徐州医学院麻醉药理学教研室,徐州221004

出　　处：《药学与临床研究》2010年第5期438-439,共2页Pharmaceutical and Clinical Research

基　　金：国家自然科学基金资助项目(39970715);江苏省自然科学基金资助项目(BK200143)

摘　　要：目的:观察异丙嗪(promethazine,Prom)对小鼠利多卡因(lidocaine)致惊厥作用的影响。方法:腹腔注射利多卡因建立小鼠惊厥模型,观察腹腔注射3种剂量的异丙嗪对小鼠惊厥持续期、惊厥发生率和死亡率的影响。结果:异丙嗪可剂量依赖性地缩短小鼠利多卡因中毒惊厥的持续期(P<0.01),但对惊厥发生率、死亡率无显著影响(P>0.05)。结论:异丙嗪缩短利多卡因惊厥持续期,有一定的抗惊厥作用。Objective： To observe the effect of promethazine on convulsion function of lidocaine in mice. Methods： We established a mouse model of convulsive by intraperitoneal injection of lidocain, then intraperitoneally injected 3 doses of promethazine respectively. We observed the effect of promethazine on convulsion duration, incidence of seizures and death rate of lidocaine in mice. Results： Promethazine can dose-dependently reduce the duration of lidocaine seizures （P〈0.01） in mice, but had no significant improvement in the incidence of seizures and mortality （P〉0.05）. Conclusion： Promethazine has a certain degree of anticonvulsant effect against lidocaine induced convulsions.

关 键 词：异丙嗪 利多卡因 药物惊厥 小鼠 

分 类 号：R969.2[医药卫生—药理学] R971.2[医药卫生—药学]