依达拉奉对脑梗死患者溶血磷脂酸、酸性磷脂酸水平的影响及疗效观察  

Effects of Edaravone on Acidic Phosphatidic Acid,Lysophosphatidic Acid and Functional Outcomes in Patients with Acute Cerebral Infarction

作　　者：张晓霞[1] 闫中瑞[1] 赵莉[1] 冯清燕[1] 岳红梅[1] 刘厚林[1] 

机构地区：[1]济宁市第一人民医院神经内科,济宁272100

出　　处：《药学与临床研究》2010年第5期465-467,共3页Pharmaceutical and Clinical Research

摘　　要：目的:观察依达拉奉对急性脑梗死患者血清溶血磷脂酸(lysophosphatidic acid,LPA)、血浆酸性磷脂酸(acidity phosphatidic acid,AP)含量的影响及临床疗效。方法:选择急性脑梗死患者200例,随机分为依达拉奉治疗组(137例)和对照组(63例)。治疗组在对照组治疗的基础上,加用依达拉奉30mg静脉滴注,2次/d,共14d。分别于治疗前和治疗后1、2、3、7、14、21d取静脉血4mL测定AP、LPA水平,并在入院时、治疗7d、14d、1个月进行神经功能缺损(CSS)评定,并在3个月、半年进行日常生活能力量表(ADL)评定,了解依达拉奉的治疗效果。结果:对照组与依达拉奉组治疗14d后LPA、AP水平均较治疗前显著降低(P<0.01),CSS、ADL评分亦显著改善(P<0.05),与对照组相比,依达拉奉组上述指标改善更明显(P<0.01)。结论:依达拉奉能降低血清LPA、AP的水平,清除自由基,改善脑梗死的预后。Objective： To investigate the effect of Edaravone on the concentrations of acidic phosphatidic acid （ALP） and lysophosphatidic acid （LPA） in serum and its clinical efficacy in patients with cerebral infarction. Methods： Patients with acute cerebral infarction were randomly assigned to Edaravone group （n= 137） and control group （n=63）. Edaravone （30 mg） was used as intravenous drip twice a clay for 14 days in the Edaravone group besides the treatment as in the control group. Venous blood samples （4 mL） were taken to measure the levels of AP and LPA before and after treatment. The CSS were evaluated before treatment and at the 7th, 14th and 30th day respectively after treatments, and the Activities of Daily Living Scale （ADL） were evaluated at the recruitment, the 3rd and 6th month respectively of the treatments. Results： The PA and LPA levels in both groups decreased after 14 days of treatment （P〈0.01）, and the CSS and ADL scores also improved in both groups （P〈0.05）. However, a marked improvement of the above indexes was observed in the Edaravone group compared with the control group （P〈0.01）. Conclusion： Edaravone can decrease AP and LPA in serum, suppress flee radicals and improve the prognosis of cerebral infarction.

关 键 词：依达拉奉 脑梗死 酸性磷脂酸 溶血磷脂酸 

分 类 号：R969.4[医药卫生—药理学]