硫酸镁联合依达拉奉治疗急性脑梗死的疗效观察  

Effect of MgSO_4 Intravenous Infusion Associated with Edaravone in the Treatment of Acute Cerebral Infarction

作　　者：纪晓军[1] 李志平[2] 裴海涛[1] 李红云[1] 王亚男[1] 郭壮丽[1] 韩迪[1] 

机构地区：[1]青岛大学医学院附属医院急诊神经科,青岛266003 [2]青岛市立医院药剂科,青岛266011

出　　处：《药学与临床研究》2010年第5期468-470,共3页Pharmaceutical and Clinical Research

摘　　要：目的:探讨依达拉奉联合应用硫酸镁静脉给药治疗急性脑梗死的疗效和最佳剂量。方法:联合治疗组患者在依达拉奉治疗的基础上给以3种负荷量的硫酸镁(0mL,10mL,20mL)加24h内60mL硫酸镁维持以及每日20mL,14d的硫酸镁维持治疗,监测患者的血压、腱反射等镁的副作用,动态观察了血清镁浓度,在30d和90d对患者进行ESS评分。结果:10mL、20mL硫酸镁联合治疗组患者的血清镁能够迅速提升,明显增加患者远期的ESS评分,其中20mL组更为有效。未见明显的不能耐受的不良反应。结论:依达拉奉联合应用硫酸镁,负荷应用硫酸镁10mL、20mL对脑梗死患者具有良好的治疗作用,其中20mL负荷量效果最佳。Objective： To observe the protective effect and optimal dose of MgSO4 infusion in association with edaravone in the treatment of acute cerebral infarction. Methods： Patients of therapeutic alliance were randomly .received a loading infusion of 0 mL, 10 mL or 20 mL of 25% MgSO4, followed by 60 mL in 24 h, and 20 mL everyday for 14 d. The blood pressure, tendon reflex, serum magnesium concentration were monitored; ESS score were recorded at 30 d and 90 d. Results： A loading 10 mL, 20 mL of 25% MgSO4 associated with edaravone can rapidly elevate the serum magnesium concentration in patients, increase the long-term ESS score, and the loading 20 mL of 25% MgSO4 infusion was the optimized dose. No serve adverse effect was observed. Conlusion： Associated with edaravone, the loading 10 mL and 20 mL of 25% MgSO4 intravenous infusion are effective in the treatment of acute cerebral infarction, and the loading dose of 20 mL is optimal.

关 键 词：急性脑梗死 依达拉奉 硫酸镁 

分 类 号：R969.4[医药卫生—药理学]